Elovl6 is a poor prognostic predictor in breast cancer

Yin Hsun Feng, Wei Yu Chen, Yu Hsuan Kuo, Chao Ling Tung, Chao Jung Tsao, Ai Li Shiau, Chao Liang Wu

研究成果: Article同行評審

19 引文 斯高帕斯(Scopus)

摘要

Elongation of long chain fatty acids family member 6 (Elovl6) has been demonstrated to be involved in insulin resistance, obesity and lipogenesis. In addition, it has been reported that the protein is upregulated in human hepatocellular carcinoma and is implicated in nonalcoholic steatohepatitis-associated liver carcinogenesis. Excess body weight has been associated with an increased risk of postmenopausal breast cancer and poor prognosis. However, the connection between Elovl6 expression and outcome of breast cancer remains uncertain. Therefore, the present study used immunohistochemical analysis to investigate the expression of Elovl6 in breast cancer tissues from patients who had undergone curative mastectomy. Out of a total of 70 patients, 37.1% of patients exhibited positive Elovl6 expression in breast cancer tissue, whilst 62.9% were considered as negative. Positive Elov16 expression correlated with positive lymph node involvement and shorter recurrence-free survival. However, Elovl6 expression had no association with primary tumor size, lymph node metastasis, stage, grade, estrogen receptor, progesterone receptor, HER2 and age. Therefore, positive Elovl6 expression is a poor prognostic factor in patients with breast cancer that have previously undergone surgery, and may function as a potential therapeutic approach in the future, particularly in the scope of obesity related disease.

原文English
頁(從 - 到)207-212
頁數6
期刊Oncology Letters
12
發行號1
DOIs
出版狀態Published - 2016 七月

All Science Journal Classification (ASJC) codes

  • 腫瘤科
  • 癌症研究

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