Emergence of ceftriaxone-resistant Salmonella isolates and rapid spread of plasmid-encoded CMY-2-like cephalosporinase, Taiwan

Jing Jou Yan, Wen Chien Ko, Cheng Hsun Chiu, Shu Huei Tsai, Hsiu Mei Wu, Jiunn Jong Wu

研究成果: Article同行評審

53 引文 斯高帕斯(Scopus)

摘要

Of 384 Salmonella isolates collected from 1997 to 2000 in a university hospital in Taiwan, six ceftriaxone-resistant isolates of Salmonella enterica serovar Typhimurium were found in two patients in 2000. The resistance determinants were on conjugative plasmids that encoded a CMY-2-like cephalosporinase. During the study period, the proportion of CMY-2-like enzyme producers among Escherichia coli increased rapidly from 0.2% in early 1999 to >4.0% in late 2000. Klebsiella pneumoniae isolates producing a CMY-2-like-lactamase did not emerge until 2000. The presence of blaCMY-containing plasmids with an identical restriction pattern from Salmonella, E. coli, and K. pneumoniae isolates was found, which suggests interspecies spread and horizontal transfer of the resistance determinant. Various nosocomial and community-acquired infections were associated with the CMY-2-like enzyme producers. Our study suggests that the spread of plasmid-mediated CMY-2-like β-lactamases is an emerging threat to hospitalized patients and the public in Taiwan.

原文English
頁(從 - 到)323-328
頁數6
期刊Emerging infectious diseases
9
發行號3
出版狀態Published - 2003 三月 1

All Science Journal Classification (ASJC) codes

  • 流行病學
  • 微生物學(醫學)
  • 傳染性疾病

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