TY - JOUR
T1 - Emergence of uncommon emm types of Streptococcus pyogenes among adult patients in southern Taiwan
AU - Chiang-Ni, Chuan
AU - Wu, An Bang
AU - Liu, Ching Chuan
AU - Chen, Kow Ton
AU - Lin, Yee Shin
AU - Chuang, Woei Jer
AU - Fang, Hsin Yi
AU - Wu, Jiunn Jong
N1 - Funding Information:
The authors are very grateful to Robert M. Jonas for helpful comments on the manuscript. This work was supported in part by grants NSC 97-2311-B-006-004-MY3 and 98-2320-B-006-006-MY3 from the National Science Council , Taiwan. The authors declare no conflict of interest relative to any source of funding, sponsorship, or financial benefit.
PY - 2011/12
Y1 - 2011/12
N2 - Background: Streptococcus pyogenes isolated from adult patients during a 12-year period in southern Taiwan were analyzed to estimate the distribution of emm types and their correlation with disease manifestations and patient age. Methods: Three hundred thirty-four invasive and noninvasive isolates collected from patients older than 20 years between 1997 and 2008 at National Cheng Kung University Hospital were included for emm typing. A correlation between emm type, disease manifestations, and patient ages was analyzed. Results: The nine most prevalent types were emm11, emm12, emm4, emm1, Sp9458/VT8, emm81, emm106, emm13, and emm75. Formerly rare emm types, including emm11, emm81, and emm102, emerged dramatically after 2004 in southern Taiwan. Type emm11 was significantly associated with both superficial infections and cellulitis. In addition, types emm13, emm81, and emm106 were more prevalent in patients older than 50 years and significantly associated with specific invasive disease manifestation. Conclusion: These results suggest new emm types (emm11, emm81, and emm102) of S pyogenes were introduced into the adult population in southern Taiwan after 2004. The rarely reported emm types, including emm13, emm81, and emm106, caused invasive diseases more often in adult patients.
AB - Background: Streptococcus pyogenes isolated from adult patients during a 12-year period in southern Taiwan were analyzed to estimate the distribution of emm types and their correlation with disease manifestations and patient age. Methods: Three hundred thirty-four invasive and noninvasive isolates collected from patients older than 20 years between 1997 and 2008 at National Cheng Kung University Hospital were included for emm typing. A correlation between emm type, disease manifestations, and patient ages was analyzed. Results: The nine most prevalent types were emm11, emm12, emm4, emm1, Sp9458/VT8, emm81, emm106, emm13, and emm75. Formerly rare emm types, including emm11, emm81, and emm102, emerged dramatically after 2004 in southern Taiwan. Type emm11 was significantly associated with both superficial infections and cellulitis. In addition, types emm13, emm81, and emm106 were more prevalent in patients older than 50 years and significantly associated with specific invasive disease manifestation. Conclusion: These results suggest new emm types (emm11, emm81, and emm102) of S pyogenes were introduced into the adult population in southern Taiwan after 2004. The rarely reported emm types, including emm13, emm81, and emm106, caused invasive diseases more often in adult patients.
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U2 - 10.1016/j.jmii.2011.04.005
DO - 10.1016/j.jmii.2011.04.005
M3 - Article
C2 - 21601543
AN - SCOPUS:83155181708
SN - 1684-1182
VL - 44
SP - 424
EP - 429
JO - Journal of Microbiology, Immunology and Infection
JF - Journal of Microbiology, Immunology and Infection
IS - 6
ER -
