Emerging methods for analysis of the cancer methylome

Jer Wei Chang, Tim Hui Ming Huang, Yi-Ching Wang

研究成果: Review article同行評審

11 引文 斯高帕斯(Scopus)

摘要

CpG island hypermethylation plays a key role in the silencing of cancer-related genes. In recent years, some new and effective methods have been developed for high-throughput analysis of DNA methylation, and have provided DNA methylation markers as powerful tools for the development of innovative diagnostic and therapeutic strategies in cancer. In this review, we describe various current and emerging technologies for studying the DNA methylation profile in cancer including: the isoschizomers and gel-based methylation analysis, the microarray-based methylation analysis and the sequencing-based methylation analysis. All of these techniques have advantages and disadvantages, such as sensitivity, specificity, analysis scale and cost. In the coming years, newer platforms of low cost, high-throughput and greater expediency, and speed for cancer methylome analysis will be developed.

原文English
頁(從 - 到)1869-1878
頁數10
期刊Pharmacogenomics
9
發行號12
DOIs
出版狀態Published - 2008 十二月 1

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Genetics
  • Pharmacology

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