emm1/sequence type 28 strains of group A streptococci that express covR at early stationary phase are associated with increased growth and earlier speB secretion

Chuan Chiang-Ni, Po Xing Zheng, Yueh Ren Ho, Hsiu Mei Wu, Woei Jer Chuang, Yee Shin Lin, Ming T. Lin, Ching Chuan Liu, Jiunn Jong Wu

研究成果: Article同行評審

14 引文 斯高帕斯(Scopus)

摘要

Streptococcus pyogenes (group A streptococcus [GAS]) is a versatile human pathogen, and emm1/sequence type 28 (ST28) is the most frequently isolated type from GAS infections. The emm1/ST28 strain is associated with necrotizing fasciitis and streptococcal toxic shock syndrome. Growth-phase regulation is one of the important regulatory mechanisms in GAS, which controls gene expression at restricted phases of growth. CovRS, a two-component regulatory system, is considered the regulator of streptococcal pyrogenic exotoxin B (SpeB) and is thought to be activated in the exponential phase of growth. In the present study, Northern hybridization analysis showed that 52% of the analyzed GAS strains expressed covR at the exponential phase, but 48% of the strains expressed covR at the early stationary phase of growth. Strains transcribing covR at the early stationary phase showed better growth and earlier SpeB expression than the other group of strains. Multilocus sequence typing and pulsed-field gel electrophoresis analysis showed only emm1/ST28 strains (which comprise a clonal cluster) were expressing covR at the early stationary phase of growth, indicating that emm1/ST28 strains have special characteristics which may be related to their worldwide distribution.

原文English
頁(從 - 到)3161-3169
頁數9
期刊Journal of Clinical Microbiology
47
發行號10
DOIs
出版狀態Published - 2009 十月

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)

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