Endoscopic variceal ligation versus conservative treatment for patients with hepatocellular carcinoma and bleeding esophageal varices

Chi Yi Chen, Ting Tsung Chang, Ching Yih Lin, Jeng Shiann Shin, Chiung Yu Chem, Chih Hsien Chi, Bor Shyang Sheu, Xi Zhang Lin

研究成果: Article

10 引文 (Scopus)

摘要

Background: Endoscopic variceal ligation (EVL) is currently a favored treatment for control of bleeding from esophageal varices. However, little is known about the treatment of bleeding varices in hepatocellular carcinoma. Methods: EVL was performed in 16 patients with bleeding esophageal varices due to concomitant hepatocellular carcinoma. Treatment results were compared with those of another 23 patients who were conservatively treated. Results: Comparing the two groups, ligation significantly reduced the risk of fatal bleeding (44% vs 70%; P < 0.05). Significantly fewer patients in the ligation group died at the time of the index hemorrhage (11% vs 52%; P < 0.05). Rebleeding occurred in 44% of the ligation group and 73% in the control group ( P 〉 0.05). The mean days of survival were 40 ± 20 (range, 7 to 103) in the ligation group and 20 ± 30 (range, 1 to 136) in the control group ( P = 0.08). In the absence of portal vein thrombosis, ligation significantly reduced the rebleeding rate (17% vs 50%, P < 0.05) and the mortality rate (0% vs 100%, P < 0.05). Conclusion: EVL is a good choice for palliation in patients with esophageal variceal bleeding and hepatocellular carcinoma. Aggressive use of EVL may be tried in those patients without portal venous thrombosis. (Gastrointest Endosc 1995;42:535-9.)

原文English
頁(從 - 到)535-539
頁數5
期刊Gastrointestinal Endoscopy
42
發行號6
DOIs
出版狀態Published - 1995 一月 1

指紋

Esophageal and Gastric Varices
Ligation
Hepatocellular Carcinoma
Hemorrhage
Conservative Treatment
Control Groups
Varicose Veins
Portal Vein
Venous Thrombosis
Thrombosis
Therapeutics
Survival
Mortality

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging
  • Gastroenterology

引用此文

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title = "Endoscopic variceal ligation versus conservative treatment for patients with hepatocellular carcinoma and bleeding esophageal varices",
abstract = "Background: Endoscopic variceal ligation (EVL) is currently a favored treatment for control of bleeding from esophageal varices. However, little is known about the treatment of bleeding varices in hepatocellular carcinoma. Methods: EVL was performed in 16 patients with bleeding esophageal varices due to concomitant hepatocellular carcinoma. Treatment results were compared with those of another 23 patients who were conservatively treated. Results: Comparing the two groups, ligation significantly reduced the risk of fatal bleeding (44{\%} vs 70{\%}; P < 0.05). Significantly fewer patients in the ligation group died at the time of the index hemorrhage (11{\%} vs 52{\%}; P < 0.05). Rebleeding occurred in 44{\%} of the ligation group and 73{\%} in the control group ( P 〉 0.05). The mean days of survival were 40 ± 20 (range, 7 to 103) in the ligation group and 20 ± 30 (range, 1 to 136) in the control group ( P = 0.08). In the absence of portal vein thrombosis, ligation significantly reduced the rebleeding rate (17{\%} vs 50{\%}, P < 0.05) and the mortality rate (0{\%} vs 100{\%}, P < 0.05). Conclusion: EVL is a good choice for palliation in patients with esophageal variceal bleeding and hepatocellular carcinoma. Aggressive use of EVL may be tried in those patients without portal venous thrombosis. (Gastrointest Endosc 1995;42:535-9.)",
author = "Chen, {Chi Yi} and Chang, {Ting Tsung} and Lin, {Ching Yih} and Shin, {Jeng Shiann} and Chem, {Chiung Yu} and Chi, {Chih Hsien} and Sheu, {Bor Shyang} and Lin, {Xi Zhang}",
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T1 - Endoscopic variceal ligation versus conservative treatment for patients with hepatocellular carcinoma and bleeding esophageal varices

AU - Chen, Chi Yi

AU - Chang, Ting Tsung

AU - Lin, Ching Yih

AU - Shin, Jeng Shiann

AU - Chem, Chiung Yu

AU - Chi, Chih Hsien

AU - Sheu, Bor Shyang

AU - Lin, Xi Zhang

PY - 1995/1/1

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N2 - Background: Endoscopic variceal ligation (EVL) is currently a favored treatment for control of bleeding from esophageal varices. However, little is known about the treatment of bleeding varices in hepatocellular carcinoma. Methods: EVL was performed in 16 patients with bleeding esophageal varices due to concomitant hepatocellular carcinoma. Treatment results were compared with those of another 23 patients who were conservatively treated. Results: Comparing the two groups, ligation significantly reduced the risk of fatal bleeding (44% vs 70%; P < 0.05). Significantly fewer patients in the ligation group died at the time of the index hemorrhage (11% vs 52%; P < 0.05). Rebleeding occurred in 44% of the ligation group and 73% in the control group ( P 〉 0.05). The mean days of survival were 40 ± 20 (range, 7 to 103) in the ligation group and 20 ± 30 (range, 1 to 136) in the control group ( P = 0.08). In the absence of portal vein thrombosis, ligation significantly reduced the rebleeding rate (17% vs 50%, P < 0.05) and the mortality rate (0% vs 100%, P < 0.05). Conclusion: EVL is a good choice for palliation in patients with esophageal variceal bleeding and hepatocellular carcinoma. Aggressive use of EVL may be tried in those patients without portal venous thrombosis. (Gastrointest Endosc 1995;42:535-9.)

AB - Background: Endoscopic variceal ligation (EVL) is currently a favored treatment for control of bleeding from esophageal varices. However, little is known about the treatment of bleeding varices in hepatocellular carcinoma. Methods: EVL was performed in 16 patients with bleeding esophageal varices due to concomitant hepatocellular carcinoma. Treatment results were compared with those of another 23 patients who were conservatively treated. Results: Comparing the two groups, ligation significantly reduced the risk of fatal bleeding (44% vs 70%; P < 0.05). Significantly fewer patients in the ligation group died at the time of the index hemorrhage (11% vs 52%; P < 0.05). Rebleeding occurred in 44% of the ligation group and 73% in the control group ( P 〉 0.05). The mean days of survival were 40 ± 20 (range, 7 to 103) in the ligation group and 20 ± 30 (range, 1 to 136) in the control group ( P = 0.08). In the absence of portal vein thrombosis, ligation significantly reduced the rebleeding rate (17% vs 50%, P < 0.05) and the mortality rate (0% vs 100%, P < 0.05). Conclusion: EVL is a good choice for palliation in patients with esophageal variceal bleeding and hepatocellular carcinoma. Aggressive use of EVL may be tried in those patients without portal venous thrombosis. (Gastrointest Endosc 1995;42:535-9.)

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