Engineered nanoparticles mimicking cell membranes for toxin neutralization

Ronnie H. Fang, Brian T. Luk, Che Ming J. Hu, Liangfang Zhang

研究成果: Review article

51 引文 斯高帕斯(Scopus)

摘要

Protein toxins secreted from pathogenic bacteria and venomous animals rely on multiple mechanisms to overcome the cell membrane barrier to inflict their virulence effect. A promising therapeutic concept toward developing a broadly applicable anti-toxin platform is to administer cell membrane mimics as decoys to sequester these virulence factors. As such, lipid membrane-based nanoparticulates are an ideal candidate given their structural similarity to cellular membranes. This article reviews the virulence mechanisms employed by toxins at the cell membrane interface and highlights the application of cell-membrane mimicking nanoparticles as toxin decoys for systemic detoxification. In addition, the implication of particle/toxin nanocomplexes in the development of toxoid vaccines is discussed.

原文English
頁(從 - 到)69-80
頁數12
期刊Advanced Drug Delivery Reviews
90
DOIs
出版狀態Published - 2015 八月 1

    指紋

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

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