TY - JOUR
T1 - Engineering Biomaterials with Micro/Nanotechnologies for Cell Reprogramming
AU - Fang, Jun
AU - Hsueh, Yuan Yu
AU - Soto, Jennifer
AU - Sun, Wujin
AU - Wang, Jinqiang
AU - Gu, Zhen
AU - Khademhosseini, Ali
AU - Li, Song
N1 - Publisher Copyright:
© 2020 American Chemical Society.
PY - 2020/2/25
Y1 - 2020/2/25
N2 - Cell reprogramming is a revolutionized biotechnology that offers a powerful tool to engineer cell fate and function for regenerative medicine, disease modeling, drug discovery, and beyond. Leveraging advances in biomaterials and micro/nanotechnologies can enhance the reprogramming performance in vitro and in vivo through the development of delivery strategies and the control of biophysical and biochemical cues. In this review, we present an overview of the state-of-the-art technologies for cell reprogramming and highlight the recent breakthroughs in engineering biomaterials with micro/nanotechnologies to improve reprogramming efficiency and quality. Finally, we discuss future directions and challenges for reprogramming technologies and clinical translation.
AB - Cell reprogramming is a revolutionized biotechnology that offers a powerful tool to engineer cell fate and function for regenerative medicine, disease modeling, drug discovery, and beyond. Leveraging advances in biomaterials and micro/nanotechnologies can enhance the reprogramming performance in vitro and in vivo through the development of delivery strategies and the control of biophysical and biochemical cues. In this review, we present an overview of the state-of-the-art technologies for cell reprogramming and highlight the recent breakthroughs in engineering biomaterials with micro/nanotechnologies to improve reprogramming efficiency and quality. Finally, we discuss future directions and challenges for reprogramming technologies and clinical translation.
UR - http://www.scopus.com/inward/record.url?scp=85081175892&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85081175892&partnerID=8YFLogxK
U2 - 10.1021/acsnano.9b04837
DO - 10.1021/acsnano.9b04837
M3 - Review article
C2 - 32011856
AN - SCOPUS:85081175892
SN - 1936-0851
VL - 14
SP - 1296
EP - 1318
JO - ACS nano
JF - ACS nano
IS - 2
ER -