TY - JOUR
T1 - Enhanced risk of traumatic brain injury in patients with chronic obstructive pulmonary disease
AU - Huang, Tang Hsiu
AU - Chen, Chiung Zuei
AU - Kuo, Hung I.
AU - Er, Hong Ping
AU - Lin, Sheng Hsiang
N1 - Funding Information:
Funding This study was supported by the National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, under grant NCKUH-10603010.
Publisher Copyright:
© © American Federation for Medical Research 2020. Re-use permitted under CC BY-NC. No commercial re-use. Published by BMJ.
PY - 2020/4/1
Y1 - 2020/4/1
N2 - This study tests our hypothesis that patients with chronic obstructive pulmonary disease (COPD) have an increased risk of traumatic brain injury (TBI). In this nationwide retrospective cohort study, we used a subset of Taiwan's National Health Insurance Research Database, involving 1 million randomly selected beneficiaries. Patients with newly diagnosed COPD between 2000 and 2008 were identified. They were subgrouped as ' COPDAE+ ' (if they had severe acute exacerbation of COPD during the follow-ups) or ' COPDAE- ' (if they had no acute exacerbation), and were frequency matched with randomly selected subjects without COPD (the ' non-COPD' group). Baseline differences were balanced by the inverse probability of treatment weighting based on the propensity score. For each patient, the risk of TBI during the subsequent 5 years was determined. The competing risk of death was controlled. We identified 3734 patients in ' COPDAE+ ', and frequency matched them with 11,202 patients in ' COPDAE- ' and 11,202 subjects in ' non-COPD'. Compared with those in ' non-COPD', patients in ' COPD AE+ ' and ' COPDAE- ' had an increased risk of TBI: the adjusted HR for ' COPDAE+ ' was 1.50, 95% CI 1.31 to 1.73, and that for ' COPDAE- ' was 1.21, 95% CI 1.09 to 1.34. The highest risk was observed in the ' COPDAE+ ' group that aged <65 (the adjusted HR was 1.92; 95% CI 1.39 to 2.64). COPD has been linked to complications beyond the respiratory system. In this study we showed that COPD is associated with an increased risk of TBI.
AB - This study tests our hypothesis that patients with chronic obstructive pulmonary disease (COPD) have an increased risk of traumatic brain injury (TBI). In this nationwide retrospective cohort study, we used a subset of Taiwan's National Health Insurance Research Database, involving 1 million randomly selected beneficiaries. Patients with newly diagnosed COPD between 2000 and 2008 were identified. They were subgrouped as ' COPDAE+ ' (if they had severe acute exacerbation of COPD during the follow-ups) or ' COPDAE- ' (if they had no acute exacerbation), and were frequency matched with randomly selected subjects without COPD (the ' non-COPD' group). Baseline differences were balanced by the inverse probability of treatment weighting based on the propensity score. For each patient, the risk of TBI during the subsequent 5 years was determined. The competing risk of death was controlled. We identified 3734 patients in ' COPDAE+ ', and frequency matched them with 11,202 patients in ' COPDAE- ' and 11,202 subjects in ' non-COPD'. Compared with those in ' non-COPD', patients in ' COPD AE+ ' and ' COPDAE- ' had an increased risk of TBI: the adjusted HR for ' COPDAE+ ' was 1.50, 95% CI 1.31 to 1.73, and that for ' COPDAE- ' was 1.21, 95% CI 1.09 to 1.34. The highest risk was observed in the ' COPDAE+ ' group that aged <65 (the adjusted HR was 1.92; 95% CI 1.39 to 2.64). COPD has been linked to complications beyond the respiratory system. In this study we showed that COPD is associated with an increased risk of TBI.
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U2 - 10.1136/jim-2019-001207
DO - 10.1136/jim-2019-001207
M3 - Article
C2 - 31892639
AN - SCOPUS:85077578316
SN - 1081-5589
VL - 68
SP - 846
EP - 855
JO - Journal of Investigative Medicine
JF - Journal of Investigative Medicine
IS - 4
ER -