Enhancement of non-homologous end joining DNA repair capacity confers cancer cells resistance to the novel selenophene compound, D-501036

Yung Ning Yang; Kai ming Chou; Wen Yu Pan; Yih wen Chen; Tsui Chun Tsou; Ssu Ching Yeh; Chun Hei Antonio Cheung; Li Tzong Chen; Jang Yang Chang

doi:10.1016/j.canlet.2011.05.023

Enhancement of non-homologous end joining DNA repair capacity confers cancer cells resistance to the novel selenophene compound, D-501036

Yung Ning Yang, Kai ming Chou, Wen Yu Pan, Yih wen Chen, Tsui Chun Tsou, Ssu Ching Yeh, Chun Hei Antonio Cheung, Li Tzong Chen, Jang Yang Chang

研究成果: Article › 同行評審

7 引文斯高帕斯（Scopus）

摘要

D-501036 is a promising anti-cancer compound that exhibits potent anti-proliferative activity against various types of human cancers through the induction of double strand DNA breaks. To determine drug resistance mechanism related to this class of DNA-damaging agents, a KB-derived D-501036-resistant cell line (S4) was established. Results showed that S4 cells exhibit enhanced DNA rejoining ability as compare to KB cells, through up-regulation of the non-homologous end joining activity. In conclusion, enhancement of NHEJ activity plays important role in the development of D-501036-resistance and targeting NHEJ-related molecules maybe able to overcome drug resistance to DNA damaging agents.

原文	English
頁（從 - 到）	110-118
頁數	9
期刊	Cancer Letters
卷	309
發行號	1
DOIs	https://doi.org/10.1016/j.canlet.2011.05.023
出版狀態	Published - 2011 10月 1

All Science Journal Classification (ASJC) codes

腫瘤科
癌症研究

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10.1016/j.canlet.2011.05.023

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title = "Enhancement of non-homologous end joining DNA repair capacity confers cancer cells resistance to the novel selenophene compound, D-501036",

abstract = "D-501036 is a promising anti-cancer compound that exhibits potent anti-proliferative activity against various types of human cancers through the induction of double strand DNA breaks. To determine drug resistance mechanism related to this class of DNA-damaging agents, a KB-derived D-501036-resistant cell line (S4) was established. Results showed that S4 cells exhibit enhanced DNA rejoining ability as compare to KB cells, through up-regulation of the non-homologous end joining activity. In conclusion, enhancement of NHEJ activity plays important role in the development of D-501036-resistance and targeting NHEJ-related molecules maybe able to overcome drug resistance to DNA damaging agents.",

author = "Yang, {Yung Ning} and Chou, {Kai ming} and Pan, {Wen Yu} and Chen, {Yih wen} and Tsou, {Tsui Chun} and Yeh, {Ssu Ching} and Cheung, {Chun Hei Antonio} and Chen, {Li Tzong} and Chang, {Jang Yang}",

note = "Funding Information: This study was supported by Grants of National Science Council ( NSC98-2323-B-400-004 and NSC99-2120-M-006-005 ), and Department of Health ( DOH99-TD-C-111-004 ), Taiwan, ROC. K.-M. Chou is supported by National Institutes of Health (NIH) Grant RO1 CA112446.",

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AU - Yang, Yung Ning

AU - Chou, Kai ming

AU - Pan, Wen Yu

AU - Chen, Yih wen

AU - Tsou, Tsui Chun

AU - Yeh, Ssu Ching

AU - Cheung, Chun Hei Antonio

AU - Chen, Li Tzong

AU - Chang, Jang Yang

N1 - Funding Information: This study was supported by Grants of National Science Council ( NSC98-2323-B-400-004 and NSC99-2120-M-006-005 ), and Department of Health ( DOH99-TD-C-111-004 ), Taiwan, ROC. K.-M. Chou is supported by National Institutes of Health (NIH) Grant RO1 CA112446.

PY - 2011/10/1

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N2 - D-501036 is a promising anti-cancer compound that exhibits potent anti-proliferative activity against various types of human cancers through the induction of double strand DNA breaks. To determine drug resistance mechanism related to this class of DNA-damaging agents, a KB-derived D-501036-resistant cell line (S4) was established. Results showed that S4 cells exhibit enhanced DNA rejoining ability as compare to KB cells, through up-regulation of the non-homologous end joining activity. In conclusion, enhancement of NHEJ activity plays important role in the development of D-501036-resistance and targeting NHEJ-related molecules maybe able to overcome drug resistance to DNA damaging agents.

AB - D-501036 is a promising anti-cancer compound that exhibits potent anti-proliferative activity against various types of human cancers through the induction of double strand DNA breaks. To determine drug resistance mechanism related to this class of DNA-damaging agents, a KB-derived D-501036-resistant cell line (S4) was established. Results showed that S4 cells exhibit enhanced DNA rejoining ability as compare to KB cells, through up-regulation of the non-homologous end joining activity. In conclusion, enhancement of NHEJ activity plays important role in the development of D-501036-resistance and targeting NHEJ-related molecules maybe able to overcome drug resistance to DNA damaging agents.

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Enhancement of non-homologous end joining DNA repair capacity confers cancer cells resistance to the novel selenophene compound, D-501036

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