Enhancement of non-homologous end joining DNA repair capacity confers cancer cells resistance to the novel selenophene compound, D-501036

Yung Ning Yang, Kai ming Chou, Wen Yu Pan, Yih wen Chen, Tsui Chun Tsou, Ssu Ching Yeh, Chun Hei Antonio Cheung, Li Tzong Chen, Jang Yang Chang

研究成果: Article

5 引文 斯高帕斯(Scopus)

摘要

D-501036 is a promising anti-cancer compound that exhibits potent anti-proliferative activity against various types of human cancers through the induction of double strand DNA breaks. To determine drug resistance mechanism related to this class of DNA-damaging agents, a KB-derived D-501036-resistant cell line (S4) was established. Results showed that S4 cells exhibit enhanced DNA rejoining ability as compare to KB cells, through up-regulation of the non-homologous end joining activity. In conclusion, enhancement of NHEJ activity plays important role in the development of D-501036-resistance and targeting NHEJ-related molecules maybe able to overcome drug resistance to DNA damaging agents.

原文English
頁(從 - 到)110-118
頁數9
期刊Cancer Letters
309
發行號1
DOIs
出版狀態Published - 2011 十月 1

    指紋

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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