Enhancing Microcirculation on Multitriggering Manner Facilitates Angiogenesis and Collagen Deposition on Wound Healing by Photoreleased NO from Hemin-Derivatized Colloids

Chia Hao Su, Wei Peng Li, Ling Chuan Tsao, Liu Chun Wang, Ya Ping Hsu, Wen Jyun Wang, Min Chiao Liao, Chin Lai Lee, Chen Sheng Yeh

研究成果: Article同行評審

66 引文 斯高帕斯(Scopus)

摘要

A deficiency of nitric oxide (NO) supply has been found to impair wound healing. The exogenous topical delivery of NO is a promising approach to enhance vasodilation and stimulate angiogenesis and collagen deposition. In this study, the CN groups on the surface of Prussian blue (PB) nanocubes were carefully reduced to -CH 2 -NH 2 to conjugate with COOH group of hemin consisting of a Fe-porphyrin structure with strong affinity toward NO. Accordingly, the NO gas was able to coordinate to hemin-modified PB nanocubes. The hemin-modified PB carrying NO (PB-NO) can be responsible to near-infrared (NIR) light (808 nm) exposure to induce the thermo-induced liberation of NO based on the light-to-heat transformation property of PB nanocubes. The NO supply on the incisional wound sites can be readily topically dropped the colloidal solution of PB-NO for receiving NIR light irradiation. The enhanced blood flow was in a controllable manner whenever the wound sites containing PB-NO received NIR light irradiation. The promotion of blood perfusion following the on-demand multidelivery of NO has effectively facilitated the process of wound closure to enhance angiogensis and collagen deposition.

原文English
頁(從 - 到)4290-4301
頁數12
期刊ACS nano
13
發行號4
DOIs
出版狀態Published - 2019 4月 23

All Science Journal Classification (ASJC) codes

  • 一般材料科學
  • 一般工程
  • 一般物理與天文學

指紋

深入研究「Enhancing Microcirculation on Multitriggering Manner Facilitates Angiogenesis and Collagen Deposition on Wound Healing by Photoreleased NO from Hemin-Derivatized Colloids」主題。共同形成了獨特的指紋。

引用此