Enhancing wound healing in recalcitrant leg ulcers with aminolevulinic acid-mediated antimicrobial photodynamic therapy

Ming Hsien Lin, Julia Yu Yun Lee, Shin Chen Pan, Tak Wah Wong

研究成果: Article同行評審

2 引文 斯高帕斯(Scopus)

摘要

Chronic leg ulcers effect millions of people around the world. It is imperative to search for effective treatments for such challenging ulcers. We report the success of aminolevulinic acid-mediated antimicrobial photodynamic therapy (A-PDT) to enhance wound healing of chronic ulcers for 3 patients who were refractory to conventional treatments. These ulcers healed after one to three sessions of A-PDT and there was no recurrence for more than 29 months. Interestingly, no bacteria were isolated from the ulcers after A-PDT treatment. In vitro, A-PDT also inactivated all bacteria isolated from the patients. A-PDT conditioned medium containing IL-6 enhanced keratinocyte migration. The results suggest in addition to bactericidal effects, A-PDT also alters the wound microenvironment. A-PDT may be an effective treatment for patients with recalcitrant infected ulcers.

原文English
文章編號102149
期刊Photodiagnosis and Photodynamic Therapy
33
DOIs
出版狀態Published - 2021 三月

All Science Journal Classification (ASJC) codes

  • 生物物理學
  • 腫瘤科
  • 皮膚科
  • 藥學(醫學)

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