Enterovirus 71: Epidemiology, pathogenesis and management

研究成果: Review article

88 引文 (Scopus)

摘要

Enterovirus 71 (EV71) has emerged as a major cause of neurological threat in the world following the eradication of poliovirus. Most EV71 infections commonly result in hand-foot-mouth disease or herpangina, and some cases are associated with brainstem encephalitis and acute flaccid paralysis. Mortality was high in EV71 brainstem encephalitis complicated with pulmonary edema, particularly in children below 5 years of age. Destruction of vasomotor in the brainstem by EV71 produces autonomic nervous system dysregulation prior to the pulmonary edema. The pulmonary edema is the result of increased pulmonary vascular permeability caused by the direct brainstem lesions and/or a systemic inflammatory response syndrome produced by the release of cytokines and chemokines. There is currently no specific antiviral agent to treat or vaccine to prevent EV71 diseases. Treating severe EV71 brainstem encephalitis patients with intravenous IgG and milrinone is associated with significantly decreased mortality by attenuated sympathetic activity and cytokine production.

原文English
頁(從 - 到)735-742
頁數8
期刊Expert Review of Anti-Infective Therapy
7
發行號6
DOIs
出版狀態Published - 2009 八月 1

指紋

Enterovirus
Brain Stem
Epidemiology
Pulmonary Edema
Encephalitis
Herpangina
Hand, Foot and Mouth Disease
Enterovirus Infections
Milrinone
Cytokines
Systemic Inflammatory Response Syndrome
Poliovirus
Mortality
Autonomic Nervous System
Capillary Permeability
Chemokines
Paralysis
Antiviral Agents
Vaccines
Immunoglobulin G

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Microbiology (medical)
  • Virology
  • Infectious Diseases

引用此文

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