Enterovirus 71 infection of human dendritic cells

研究成果: Article同行評審

64 引文 斯高帕斯(Scopus)

摘要

Enterovirus 71 (EV71) causes death and long-term neurologic sequelae in hundreds of thousands of young children, but its pathogenesis remains elusive. Dendritic cells (DCs) play a crucial role in antiviral immunity by functioning as professional antigen-presenting cells to prime T cells and by secreting cytokines to modulate immune responses. Here, we show that EV71 productively infected human immature DCs and expressed viral antigen in DCs. EV71 entry into DCs was partially mediated by DC-SIGN. Further analyses revealed that EV71 increased the viability, activation, release of cytokines, interleukin-6, interleukin-12, and tumor necrosis factor-α in DCs. Moreover, EV71 enabled DCs to stimulate T-cell proliferation. Collectively, these findings suggest that EV71 infection of human DCs in vivo is very likely to elicit protective immunity, because in infected mice, both T cells and IL-6 function to reduce mortality.

原文English
頁(從 - 到)1166-1173
頁數8
期刊Experimental Biology and Medicine
234
發行號10
DOIs
出版狀態Published - 2009 10月

All Science Journal Classification (ASJC) codes

  • 生物化學、遺傳與分子生物學 (全部)

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