Enterovirus 71 infection of monocytes with antibody-dependent enhancement

Shih-Min Wang, I. Chun Chen, Ling Yao Su, Kao Jean Huang, Huan Yao Lei, Ching-Chuan Liu

研究成果: Article

37 引文 (Scopus)

摘要

Enterovirus (EV) is an RNA virus that has circulated with different serotypes and genotypes worldwide. Enterovirus 71 (EV71) is a major neurotropic virus that causes severe brain stem encephalitis (BE) in infants and young children. The most vulnerable age for fatal infection is 6 to 11 months. This is associated with the coincident decline in maternal antibodies. The current report describes our finding that EV71 can infect human peripheral blood monocytes. We were able to show that EV71 infection is enhanced in the monocytic cell line THP-1 by the presence of subneutralizing concentrations of anti-EV71 antibodies. We also found that antibody-dependent enhancement (ADE) is mediated in part by Fcγ receptors. These observations support the concept that ADE augments the infectivity of EV71 for human monocytes and contributes to the age-dependent pathogenesis of EV71-induced disease. The ADE phenomenon must be considered during the development of an EV71 vaccine.

原文English
頁(從 - 到)1517-1523
頁數7
期刊Clinical and Vaccine Immunology
17
發行號10
DOIs
出版狀態Published - 2010 十月 1

指紋

Antibody-Dependent Enhancement
Enterovirus Infections
Enterovirus
Monocytes
Antibodies
Viruses
Human Enterovirus A
Fc Receptors
RNA Viruses
Encephalitis
Brain
Blood
Vaccines
Brain Stem
Cells
RNA
Genotype
Mothers
Cell Line
Infection

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Clinical Biochemistry
  • Microbiology (medical)

引用此文

Wang, Shih-Min ; Chen, I. Chun ; Su, Ling Yao ; Huang, Kao Jean ; Lei, Huan Yao ; Liu, Ching-Chuan. / Enterovirus 71 infection of monocytes with antibody-dependent enhancement. 於: Clinical and Vaccine Immunology. 2010 ; 卷 17, 編號 10. 頁 1517-1523.
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Enterovirus 71 infection of monocytes with antibody-dependent enhancement. / Wang, Shih-Min; Chen, I. Chun; Su, Ling Yao; Huang, Kao Jean; Lei, Huan Yao; Liu, Ching-Chuan.

於: Clinical and Vaccine Immunology, 卷 17, 編號 10, 01.10.2010, p. 1517-1523.

研究成果: Article

TY - JOUR

T1 - Enterovirus 71 infection of monocytes with antibody-dependent enhancement

AU - Wang, Shih-Min

AU - Chen, I. Chun

AU - Su, Ling Yao

AU - Huang, Kao Jean

AU - Lei, Huan Yao

AU - Liu, Ching-Chuan

PY - 2010/10/1

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AB - Enterovirus (EV) is an RNA virus that has circulated with different serotypes and genotypes worldwide. Enterovirus 71 (EV71) is a major neurotropic virus that causes severe brain stem encephalitis (BE) in infants and young children. The most vulnerable age for fatal infection is 6 to 11 months. This is associated with the coincident decline in maternal antibodies. The current report describes our finding that EV71 can infect human peripheral blood monocytes. We were able to show that EV71 infection is enhanced in the monocytic cell line THP-1 by the presence of subneutralizing concentrations of anti-EV71 antibodies. We also found that antibody-dependent enhancement (ADE) is mediated in part by Fcγ receptors. These observations support the concept that ADE augments the infectivity of EV71 for human monocytes and contributes to the age-dependent pathogenesis of EV71-induced disease. The ADE phenomenon must be considered during the development of an EV71 vaccine.

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