Environmental tobacco smoke exposure, urine CC-16 levels, and asthma outcomes among Chinese children

Y. N. Ma, Z. Qian, J. Wang, E. Rodemich, Y. L. Lee, X. F. Lv, Y. Q. Liu, Y. Zhao, M. M. Huang, Y. Liu, J. Sun, Q. C. He, G. H. Dong

研究成果: Article同行評審

6 引文 斯高帕斯(Scopus)

摘要

Background Previous studies have shown the relationship between club cell secretory protein (Clara) (CC-16) and respiratory diseases. However, few studies have explored the associations between urine CC-16 levels and environmental tobacco smoke (ETS) exposure in children. The objective of this study was to evaluate whether ETS exposure is associated with CC-16 when stratified by asthma status. Methods In our study, CC-16 was measured on 537 children aged 9-15 from northeast China in 2011-2012 using the Human Clara Cell Protein ELISA kits. Doctor-diagnosed asthma was defined as having ever been diagnosed with asthma by a physician. The relationship between ETS exposure and urine CC-16 level was assessed using linear regression. Results When stratified by asthma status, a negative association between ETS exposure and urine CC-16 was observed after adjusting for the effects of the related covariates, with an adjusted β coefficient [P value] = -0.31 [0.006] in the first 2 years of life and with an adjusted β coefficient [P value] = -0.68 [0.004] in the first 2 years of life and current. Conclusions Our study shows long-term exposure to ETS was associated with urinary CC-16 among children without asthma.

原文English
頁(從 - 到)295-301
頁數7
期刊Allergy: European Journal of Allergy and Clinical Immunology
70
發行號3
DOIs
出版狀態Published - 2015 3月 1

All Science Journal Classification (ASJC) codes

  • 免疫學和過敏
  • 免疫學

指紋

深入研究「Environmental tobacco smoke exposure, urine CC-16 levels, and asthma outcomes among Chinese children」主題。共同形成了獨特的指紋。

引用此