Epidemiology analysis of streptococcus pyogenes in a hospital in Southern Taiwan by use of the updated emm cluster typing system

Chuan Chiang-Ni, Po Xing Zheng, Shu Ying Wang, Pei Jane Tsai, Woei Jer Chuang, Yee Shin Lin, Ching Chuan Liu, Jiunn Jong Wu

研究成果: Article

2 引文 (Scopus)

摘要

emm typing is the most widely used molecular typing method for the human pathogen Streptococcus pyogenes (group A streptococcus [GAS]). emm typing is based on a small variable region of the emm gene; however, the emm cluster typing system defines GAS types according to the nearly complete sequence of the emm gene. Therefore, emm cluster typing is considered to provide more information regarding the functional and structural properties ofMproteins in different emm types of GAS. In the present study, 677 isolates collected between 1994 and 2008 in a hospital in southern Taiwan were analyzed by the emm cluster typing system. emm clusters A-C4, E1, E6, and A-C3 were the most prevalent emm cluster types and accounted for 67.4% of total isolates. emm clusters A-C4 and E1 were associated with noninvasive diseases, whereas E6 was significantly associated with both invasive and noninvasive manifestations. In addition, emm clusters D4, E2, and E3 were significantly associated with invasive manifestations. Furthermore, we found that the functional properties ofMprotein, including low fibrinogen-binding and high IgG-binding activities, were correlated significantly with invasive manifestations. In summary, the present study provides updated epidemiological information on GAS emm cluster types in southern Taiwan.

原文English
頁(從 - 到)157-162
頁數6
期刊Journal of Clinical Microbiology
54
發行號1
DOIs
出版狀態Published - 2016 一月

指紋

Streptococcus pyogenes
Streptococcus
Taiwan
Epidemiology
Molecular Typing
Fibrinogen
Genes
Immunoglobulin G

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)

引用此文

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title = "Epidemiology analysis of streptococcus pyogenes in a hospital in Southern Taiwan by use of the updated emm cluster typing system",
abstract = "emm typing is the most widely used molecular typing method for the human pathogen Streptococcus pyogenes (group A streptococcus [GAS]). emm typing is based on a small variable region of the emm gene; however, the emm cluster typing system defines GAS types according to the nearly complete sequence of the emm gene. Therefore, emm cluster typing is considered to provide more information regarding the functional and structural properties ofMproteins in different emm types of GAS. In the present study, 677 isolates collected between 1994 and 2008 in a hospital in southern Taiwan were analyzed by the emm cluster typing system. emm clusters A-C4, E1, E6, and A-C3 were the most prevalent emm cluster types and accounted for 67.4{\%} of total isolates. emm clusters A-C4 and E1 were associated with noninvasive diseases, whereas E6 was significantly associated with both invasive and noninvasive manifestations. In addition, emm clusters D4, E2, and E3 were significantly associated with invasive manifestations. Furthermore, we found that the functional properties ofMprotein, including low fibrinogen-binding and high IgG-binding activities, were correlated significantly with invasive manifestations. In summary, the present study provides updated epidemiological information on GAS emm cluster types in southern Taiwan.",
author = "Chuan Chiang-Ni and Zheng, {Po Xing} and Wang, {Shu Ying} and Tsai, {Pei Jane} and Chuang, {Woei Jer} and Lin, {Yee Shin} and Liu, {Ching Chuan} and Wu, {Jiunn Jong}",
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AU - Chiang-Ni, Chuan

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AU - Tsai, Pei Jane

AU - Chuang, Woei Jer

AU - Lin, Yee Shin

AU - Liu, Ching Chuan

AU - Wu, Jiunn Jong

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