Epidermal growth factor receptor mutation status in stage i lung adenocarcinoma with different image patterns

Kuo Hsuan Hsu, Kun Chieh Chen, Tsung Ying Yang, Yi Chen Yeh, Teh Ying Chou, Hsuan Yu Chen, Chi Ren Tsai, Chih Yi Chen, Chung Ping Hsu, Jiun Yi Hsia, Cheng Yen Chuang, Ying Huang Tsai, Kuan Yu Chen, Ming Shyan Huang, Wu Chou Su, Yuh Min Chen, Chao A. Hsiung, Gee Chen Chang, Chien Jen Chen, Pan Chyr Yang

研究成果: Article

34 引文 斯高帕斯(Scopus)

摘要

Purpose: Early lung adenocarcinoma may present with ground-glass opacity (GGO) component in computed tomography (CT) scan. Epidermal growth factor receptor (EGFR) mutation had been reported in patients with lung cancer with GGO patterns. Nevertheless, the correlation between clinical characteristics, CT image patterns, and EGFR mutation status was indeterminate. Methods: Patients with stage I lung adenocarcinoma with tumor lesions less than 3 cm were included and classified into pure GGO, part-solid, and solid patterns by CT scan images. All patients had EGFR mutation test from frozen tumors. Available paraffin-embedded archival tissues were microdissected into three different locations similar to CT images with central and peripheral parts of tumor, and adjacent normal part for EGFR mutation tests. Results: Totally, 162 patients were analyzed, 90 women and 72 men, and 128 nonsmokers. The patients included 35 (21.6%) pure GGO, 41 (25.3%) part-solid, and 86 (53.1%) solid lesions. The EGFR mutation rate was 64.2% (n = 104). Analysis of the correlation between CT image patterns and EGFR mutation, the less GGO ratio had more typical mutation, especially L858R (p = 0.037). In 45 microdissected tumors, the central and peripheral parts had the same EGFR mutation status. In adjacent normal parts, 5 of 32 (15.6%) EGFR mutant patients had identical mutation but none in nonmutant patients. Conclusions: In stage I lung adenocarcinoma, typical mutation, especially L858R was detected more frequent in invasive solid pattern and significantly less in pure GGO pattern. EGFR mutation is an early event in the pathogenesis of lung adenocarcinoma and may facilitate the tumor into aggressive behavior.

原文English
頁(從 - 到)1066-1072
頁數7
期刊Journal of Thoracic Oncology
6
發行號6
DOIs
出版狀態Published - 2011 六月

All Science Journal Classification (ASJC) codes

  • Oncology
  • Pulmonary and Respiratory Medicine

指紋 深入研究「Epidermal growth factor receptor mutation status in stage i lung adenocarcinoma with different image patterns」主題。共同形成了獨特的指紋。

  • 引用此

    Hsu, K. H., Chen, K. C., Yang, T. Y., Yeh, Y. C., Chou, T. Y., Chen, H. Y., Tsai, C. R., Chen, C. Y., Hsu, C. P., Hsia, J. Y., Chuang, C. Y., Tsai, Y. H., Chen, K. Y., Huang, M. S., Su, W. C., Chen, Y. M., Hsiung, C. A., Chang, G. C., Chen, C. J., & Yang, P. C. (2011). Epidermal growth factor receptor mutation status in stage i lung adenocarcinoma with different image patterns. Journal of Thoracic Oncology, 6(6), 1066-1072. https://doi.org/10.1097/JTO.0b013e31821667b0