Epinephrine protects against severe acute gastric bleeding in rats: Role of nitric oxide and glutathione

Dur Zong Hsu, Shan-Tair Wang, Jou Fang Deng, Ming-Yi Liu

研究成果: Article同行評審

14 引文 斯高帕斯(Scopus)

摘要

The aim of this study was to examine the effect of the systemic administration of epinephrine against severe acute gastric bleeding in rats. Epinephrine decreased gastric hemorrhage not only before but also after lipopolysaccharide-induced severe acute gastric bleeding. Epinephrine ameliorated severe gastric hemorrhage and decreased gastric mucosal lipid peroxidation through α- and β-adrenoceptors. Epinephrine modulated α-adrenoceptors to increase the levels of gastric mucosal nitric oxide and glutathione. Nitric oxide synthase inhibitors potently reversed the effects of epinephrine on gastric mucosal glutathione. Thus, epinephrine might act through α-adrenoceptors to increase the levels of gastric mucosal nitric oxide and glutathione and thus protect against severe acute gastric bleeding in rats.

原文English
頁(從 - 到)253-257
頁數5
期刊Shock
23
發行號3
DOIs
出版狀態Published - 2005 三月 1

All Science Journal Classification (ASJC) codes

  • Emergency Medicine
  • Critical Care and Intensive Care Medicine

指紋 深入研究「Epinephrine protects against severe acute gastric bleeding in rats: Role of nitric oxide and glutathione」主題。共同形成了獨特的指紋。

引用此