Epitranscriptome and fmrp regulated mrna translation

Pritha Majumder, Biswanath Chatterjee, C. K. James Shen

研究成果: Review article同行評審

1 引文 斯高帕斯(Scopus)

摘要

An important regulatory mechanism affecting mRNA translation involves various covalent modifications of RNA, which establish distinct epitranscriptomic signatures that actively influence various physiological processes. Dendritic translation in mammalian neurons is a potent target for RNA modification-based regulation. In this mini-review, we focus on the effect of potential RNA modifications on the spatiotemporal regulation of the dendritic translation of mRNAs, which are targeted by two important neuronal translational co-regulators, namely TDP-43 and Fragile X Mental Retardation Protein (FMRP).

原文English
文章編號11
期刊Epigenomes
1
發行號2
DOIs
出版狀態Published - 2017 9月

All Science Journal Classification (ASJC) codes

  • 生物化學
  • 生物化學、遺傳與分子生物學(雜項)
  • 遺傳學
  • 健康、毒理學和誘變

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