Estimated daily intake and cumulative risk assessment of phthalates in the general Taiwanese after the 2011 DEHP food scandal

Jung Wei Chang, Ching Chang Lee, Wen Harn Pan, Wei Chun Chou, Han Bin Huang, Hung Che Chiang, Po Chin Huang

研究成果: Article同行評審

28 引文 斯高帕斯(Scopus)

摘要

A food scandal occurred in Taiwan in 2011 because the DEHP (di-2-ethylhexyl phthalate) had been intentionally used in food products. We assessed the daily intakes (DIs) and cumulative risk of phthalates in Taiwan's general population after the scandal. The DIs of 6 phthalates, including di-n-butyl phthalate (DnBP), di-iso-butyl phthalate (DiBP), and DEHP, were evaluated using urinary phthalate metabolites. Hazard quotients of phthalates classified as affecting the reproductive (HQrep) and hepatic (HQhep) systems were assessed using cumulative approach. The creatinine-based model showed that the highest DI values in children 7-to 12- years-old were for DEHP (males: median: 4.79 μg/kg bw/d; females: median: 2.62 μg/kg bw/d). The 95th percentile (P95) of HQrep values were all >1 in the 7- to 12-year-old and 18- to 40-year-old male groups. The P95 of HQhep values were all >1 in the 7- to 18- year-old male groups. Most of the HQrep was attributable to the HQs of DnBP and DiBP (53.9-84.7%), and DEHP contributed most to HQhep (83.1-98.6%), which reveals that DnBP, DiBP and DEHP were the main risk of phthalate exposure for Taiwanese. Taiwan's general population is widely exposed to DnBP, DiBP and DEHP, especially for young children.

原文English
文章編號45009
期刊Scientific reports
7
DOIs
出版狀態Published - 2017 三月 22

All Science Journal Classification (ASJC) codes

  • General

指紋 深入研究「Estimated daily intake and cumulative risk assessment of phthalates in the general Taiwanese after the 2011 DEHP food scandal」主題。共同形成了獨特的指紋。

引用此