Ethanol inhibits epileptiform activity and NMDA receptor-mediated Synaptic transmission in rat amygdaloid slices

研究成果: Article同行評審

14 引文 斯高帕斯(Scopus)

摘要

The effect of ethanol on the epileptiform activity induced by Mg++-free solution was studied in rat amygdalar slices using intracellular recording techniques. The spontaneous and evoked epileptiform discharges consisting of an initial burst followed by afterdischarges were observed 20-30 min after switching to Mg++-free medium. Superfusion with ethanol (20-100 mM) reversibly reduced the duration of spontaneous and evoked bursting discharges in a concentrationdependent manner. Synaptic response mediated by N-methyl-D-aspartate (NMDA) receptor activation was isolated by application of a solution containing the non-NMDA receptor antagonist 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) and either in Mg++-free solution or in the presence of 50 μM bicuculline. Application of ethanol reversibly suppressed the duration of NMDA receptor-mediated synaptic response. These results suggest that intoxicating concentrations of ethanol possess anticonvulsant activity through blocking the NMDA receptor-mediated synaptic excitation. In addition, the observed effect of ethanol on NMDA receptor-mediated synaptic response could be relevant to the cognitive and behavioral manifestations seen in some alcoholics.

原文English
頁(從 - 到)417-421
頁數5
期刊Brain Research Bulletin
28
發行號3
DOIs
出版狀態Published - 1992 三月

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

指紋 深入研究「Ethanol inhibits epileptiform activity and NMDA receptor-mediated Synaptic transmission in rat amygdaloid slices」主題。共同形成了獨特的指紋。

引用此