Evaluation Efficacy of Rhenium-188-Loaded Micro-particles for Radiotherapy in a Mouse Model of Hepatocellular Carcinoma

Ying Hsia Shih, Cheng Liang Peng, Mao Feng Weng, Ping Fang Chiang, Tsai Yueh Luo, Xi Zhang Lin

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摘要

Hepatocellular carcinoma (HCC) is one of the leading causes of mortality worldwide. The aim of the present study was to evaluate the distribution and the therapeutic effect of 188 Re-Tin-colloid micro-particles in subcutaneous HCC-bearing mice. The synthesis and characterization of micro-particles labeled with the 188 Re isotope were performed. The micro-particles were injected into the tumor site subcutaneously in the BNL HCC-bearing mice with three treatment groups, normal saline, 188 Re micro-particles, and 188 Re-Tin-colloid micro-particles. The results of biodistribution showed that major radioactivity ( 188 Re) of 188 Re-Tin-colloid micro-particles (18.69 ± 4.28 %ID/g) remained at the tumor sites, compared with 188 Re micro-particles (0.21 ± 0.12 %ID/g), 24 h post injection. Following the injection of 188 Re-Tin-colloid micro-particles for 14 days, all BNL tumors in mice were regressed during the observation period. By contrast, all of the mice treated with normal saline or 188 Re micro-particles had died by 24 and 28 days, respectively. The 188 Re-Tin-colloid micro-particles demonstrated high accumulation and therapeutic potential in the subcutaneous HCC-bearing mice.

原文English
頁(從 - 到)1083-1091
頁數9
期刊Molecular Pharmaceutics
16
發行號3
DOIs
出版狀態Published - 2019 三月 4

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery

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