Exercise pretraining attenuates endotoxin-induced hemodynamic alteration in type I diabetic rats

Ching Hsia Hung, Yu Wen Chen, Dong Zi Shao, Che Ning Chang, Yung Yuh Tsai, Juei Tang Cheng

研究成果: Article

7 引文 (Scopus)

摘要

Higher expression of heat shock protein 72 (HSP72) reduces the mortality rate and organ damage in septic shock and prevents cardiac mitochondrial dysfunction due to lipopolysaccharide (LPS). Our hypothesis is that exercise preconditioning may increase the expression of HSP72 in heart and the nucleus tractus solitarii (NTS) of the brain to alleviate the cardiovascular dysfunction in type I diabetic rats receiving endotoxin. Wistar rats were randomly assigned to the following groups: sedentary normal, sedentary type I diabetic rats, and type I diabetic rats with exercise training. The trained rats ran on a treadmill 5 d·week-1, 30-60 min·d-1, at an intensity of 1.0 mile·h-1 (1 mile = 1.6 km) over a 3 week period. Twenty-four hours after the last training session, we compared the temporal profiles of mean arterial pressure, heart rate, cardiac output, stroke volume, and serum tumor necrosis factor α level in rats receiving an injection of LPS. In addition, HSP72 expression in heart and NTS from each group was determined. We found that HSP72 expression in the heart and NTS was significantly increased in diabetic rats with exercise training. After administration of LPS, the survival time was significantly longer in diabetic rats with exercise training. Additionaly, serum tumor necrosis factor a levels decreased as compared with those rats not receiving exercise training. Exercise training also diminished cardiovascular dysfunction in diabetic rats during endotoxemia. These data suggest that exercise may increase the expression of HSP72 in the heart and NTS to protect against the high mortality rate and attenuate cardiovascular dysfunction in diabetic rats during endotoxemia.

原文English
頁(從 - 到)976-983
頁數8
期刊Applied Physiology, Nutrition and Metabolism
33
發行號5
DOIs
出版狀態Published - 2008 十月 1

指紋

Endotoxins
Hemodynamics
HSP72 Heat-Shock Proteins
Solitary Nucleus
Exercise
Lipopolysaccharides
Endotoxemia
Tumor Necrosis Factor-alpha
Mortality
Septic Shock
Serum
Cardiac Output
Stroke Volume
Wistar Rats
Arterial Pressure
Heart Rate
Injections
Brain

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Physiology
  • Nutrition and Dietetics
  • Physiology (medical)

引用此文

Hung, Ching Hsia ; Chen, Yu Wen ; Shao, Dong Zi ; Chang, Che Ning ; Tsai, Yung Yuh ; Cheng, Juei Tang. / Exercise pretraining attenuates endotoxin-induced hemodynamic alteration in type I diabetic rats. 於: Applied Physiology, Nutrition and Metabolism. 2008 ; 卷 33, 編號 5. 頁 976-983.
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abstract = "Higher expression of heat shock protein 72 (HSP72) reduces the mortality rate and organ damage in septic shock and prevents cardiac mitochondrial dysfunction due to lipopolysaccharide (LPS). Our hypothesis is that exercise preconditioning may increase the expression of HSP72 in heart and the nucleus tractus solitarii (NTS) of the brain to alleviate the cardiovascular dysfunction in type I diabetic rats receiving endotoxin. Wistar rats were randomly assigned to the following groups: sedentary normal, sedentary type I diabetic rats, and type I diabetic rats with exercise training. The trained rats ran on a treadmill 5 d·week-1, 30-60 min·d-1, at an intensity of 1.0 mile·h-1 (1 mile = 1.6 km) over a 3 week period. Twenty-four hours after the last training session, we compared the temporal profiles of mean arterial pressure, heart rate, cardiac output, stroke volume, and serum tumor necrosis factor α level in rats receiving an injection of LPS. In addition, HSP72 expression in heart and NTS from each group was determined. We found that HSP72 expression in the heart and NTS was significantly increased in diabetic rats with exercise training. After administration of LPS, the survival time was significantly longer in diabetic rats with exercise training. Additionaly, serum tumor necrosis factor a levels decreased as compared with those rats not receiving exercise training. Exercise training also diminished cardiovascular dysfunction in diabetic rats during endotoxemia. These data suggest that exercise may increase the expression of HSP72 in the heart and NTS to protect against the high mortality rate and attenuate cardiovascular dysfunction in diabetic rats during endotoxemia.",
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Exercise pretraining attenuates endotoxin-induced hemodynamic alteration in type I diabetic rats. / Hung, Ching Hsia; Chen, Yu Wen; Shao, Dong Zi; Chang, Che Ning; Tsai, Yung Yuh; Cheng, Juei Tang.

於: Applied Physiology, Nutrition and Metabolism, 卷 33, 編號 5, 01.10.2008, p. 976-983.

研究成果: Article

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