Exercise pretraining protects against cerebral ischaemia induced by heat stroke in rats

Yu Wen Chen, Sheng Hsien Chen, Willy Chou, Yi Ming Lo, Ching Hsia Hung, Mao Tsun Lin

研究成果: Article

30 引文 (Scopus)

摘要

Background: In the rat brain, heat-stroke-induced damage to cerebral neurons is attenuated through heat-shock-induced overexpression of heat-shock protein 72 (HSP72). Objective: To ascertain whether progressive exercise preconditioning induces HSP72 expression in the rat brain and prevents heat-stroke-induced cerebral ischaemia and injury. Methods: Male Wistar rats were randomly assigned to either a sedentary group or an exercise group. Those in the exercise group progressively ran on a treadmill 5 days/week, for 30-60 min/day at an intensity of 20-30 m/min for 3 weeks. The effects of heat stroke on mean arterial pressure, cerebral blood flow, brain ischaemia markers (glulamate, lactate/pyruvate ratio and nitric oxide), a cerebral injury marker (glycerol) and brain neuronal damage score in the preconditioned animals were compared with effects in unexercised controls. Heat stroke was induced by exposing urethane-anaesthetised animals to a temperature of 43°C for 55 min, which caused the body temperature to reach 42°C. Results: Three weeks of progressive exercise pretreatment induced HSP72 preconditioning in the brain and conferred significant protection against heat-stroke-induced hyperthermia, arterial hypotension, cerebral ischaemia and neuronal damage; it also prolonged survival. Conclusions: Exercise for 3 weeks can improve heat tolerance as well as attenuate heat-stroke-induced cerebral ischaemia in rats. The maintenance of mean arterial pressure and cerebral blood flow at appropriate levels in the rat brain may be related to overexpression of HSP72.

原文English
頁(從 - 到)597-602
頁數6
期刊British Journal of Sports Medicine
41
發行號9
DOIs
出版狀態Published - 2007 九月 1

指紋

Heat Stroke
Brain Ischemia
HSP72 Heat-Shock Proteins
Cerebrovascular Circulation
Brain
Arterial Pressure
Induced Hyperthermia
Urethane
Wounds and Injuries
Body Temperature
Pyruvic Acid
Hypotension
Glycerol
Wistar Rats
Shock
Lactic Acid
Nitric Oxide
Hot Temperature
Maintenance
Neurons

All Science Journal Classification (ASJC) codes

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

引用此文

Chen, Yu Wen ; Chen, Sheng Hsien ; Chou, Willy ; Lo, Yi Ming ; Hung, Ching Hsia ; Lin, Mao Tsun. / Exercise pretraining protects against cerebral ischaemia induced by heat stroke in rats. 於: British Journal of Sports Medicine. 2007 ; 卷 41, 編號 9. 頁 597-602.
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abstract = "Background: In the rat brain, heat-stroke-induced damage to cerebral neurons is attenuated through heat-shock-induced overexpression of heat-shock protein 72 (HSP72). Objective: To ascertain whether progressive exercise preconditioning induces HSP72 expression in the rat brain and prevents heat-stroke-induced cerebral ischaemia and injury. Methods: Male Wistar rats were randomly assigned to either a sedentary group or an exercise group. Those in the exercise group progressively ran on a treadmill 5 days/week, for 30-60 min/day at an intensity of 20-30 m/min for 3 weeks. The effects of heat stroke on mean arterial pressure, cerebral blood flow, brain ischaemia markers (glulamate, lactate/pyruvate ratio and nitric oxide), a cerebral injury marker (glycerol) and brain neuronal damage score in the preconditioned animals were compared with effects in unexercised controls. Heat stroke was induced by exposing urethane-anaesthetised animals to a temperature of 43°C for 55 min, which caused the body temperature to reach 42°C. Results: Three weeks of progressive exercise pretreatment induced HSP72 preconditioning in the brain and conferred significant protection against heat-stroke-induced hyperthermia, arterial hypotension, cerebral ischaemia and neuronal damage; it also prolonged survival. Conclusions: Exercise for 3 weeks can improve heat tolerance as well as attenuate heat-stroke-induced cerebral ischaemia in rats. The maintenance of mean arterial pressure and cerebral blood flow at appropriate levels in the rat brain may be related to overexpression of HSP72.",
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Exercise pretraining protects against cerebral ischaemia induced by heat stroke in rats. / Chen, Yu Wen; Chen, Sheng Hsien; Chou, Willy; Lo, Yi Ming; Hung, Ching Hsia; Lin, Mao Tsun.

於: British Journal of Sports Medicine, 卷 41, 編號 9, 01.09.2007, p. 597-602.

研究成果: Article

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