TY - JOUR
T1 - Exogenous dehydroepiandrosterone modified the expression of T helper- related cytokines in NZB/NZW F1 mice
AU - Yang, B. C.
AU - Liu, C. W.
AU - Chen, Y. C.
AU - Yu, C. K.
N1 - Funding Information:
This research was supported by grand &om the National Science Council, ROC, [NSC
PY - 1998
Y1 - 1998
N2 - The onset of lupus-like disease in NZB/NZW F1 mice was correlated with the expression of IL-10 at 4 m of age, and with a sequential enhanced expression of IFN-γ and IL-6 between 6 to 8 m of age. The expression of IFN- γ and IL-6 was associated with exacerbation of disease symptom, production of anti-DNA antibody, and increase in total serum IgG1. Exogenous dehydroepiandrosterone (DHEA) given in animal diet significantly prolonged survival, and delayed formation of autoantibody of NZB/NZW F1 mice as compared to mice fed on control diet. The effect of DHEA paralleled a delay in the expression of IL-10 and IL-6 and an earlier detection of IL-12 transcripts. Moreover, DHEA-fed mice had higher serum IgG2a level than control diet-fed mice. Collectively, DHEA may modify the activation of distinct subset of T helper cells in NZB/NZW F1 mice at different phases of disease progression.
AB - The onset of lupus-like disease in NZB/NZW F1 mice was correlated with the expression of IL-10 at 4 m of age, and with a sequential enhanced expression of IFN-γ and IL-6 between 6 to 8 m of age. The expression of IFN- γ and IL-6 was associated with exacerbation of disease symptom, production of anti-DNA antibody, and increase in total serum IgG1. Exogenous dehydroepiandrosterone (DHEA) given in animal diet significantly prolonged survival, and delayed formation of autoantibody of NZB/NZW F1 mice as compared to mice fed on control diet. The effect of DHEA paralleled a delay in the expression of IL-10 and IL-6 and an earlier detection of IL-12 transcripts. Moreover, DHEA-fed mice had higher serum IgG2a level than control diet-fed mice. Collectively, DHEA may modify the activation of distinct subset of T helper cells in NZB/NZW F1 mice at different phases of disease progression.
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U2 - 10.3109/08820139809070902
DO - 10.3109/08820139809070902
M3 - Article
C2 - 9730089
AN - SCOPUS:0031722325
SN - 0882-0139
VL - 27
SP - 291
EP - 302
JO - Immunological Investigations
JF - Immunological Investigations
IS - 4-5
ER -