Experience with primary urethral carcinoma from the blackfoot disease-endemic area of South Taiwan: Increased frequency of bulbomembranous adenocarcinoma?

Yuh Shyan Tsai, Wen Horng Yang, Yat Ching Tong, Johnny S.N. Lin, Chen Ching Pan, Tzong Shin Tzai

研究成果: Article

8 引文 (Scopus)

摘要

Objectives: To describe and compare primary urethral carcinomas in South Taiwan with those in the USA and to explore the influence of chronic arsenic exposure. Methods: From 1988 to 2001, there were 21 pathologically proven primary urethral carcinomas diagnosed and treated at our hospital (14 males, 7 females). Seven of 14 male patients were chronically exposed to arsenic in drinking water for an average of 23 years. We compared our cases to three studies in the USA (80 males, 179 females), and analyzed the influence of chronic arsenic exposure by onset age, histology, staging, and outcome. Results: Male patients with localized tumors had better survival compared to those with advanced tumors (p = 0.0045 in males, p = 0.07 in females). In comparison to the three studies in the USA, there was an unusual higher frequency of bulbomembranous adenocarcinoma at our center (43 vs. 18%, 2 and 0%, respectively, p < 0.0001), particularly among those with chronic arsenic exposure (73 vs. 14%, p = 0.031). Conclusions: In South Taiwan, there was a high frequency of bulbomembranous urethral adenocarcinoma, which might be associated with chronic arsenic exposure. Although the implications of such an observation are minimal owing to its rarity, it is worth exploring.

原文English
頁(從 - 到)229-234
頁數6
期刊Urologia Internationalis
74
發行號3
DOIs
出版狀態Published - 2005 四月 1

指紋

Endemic Diseases
Arsenic
Taiwan
Adenocarcinoma
Carcinoma
Age of Onset
Drinking Water
Neoplasms
Histology
Observation
Survival

All Science Journal Classification (ASJC) codes

  • Urology

引用此文

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title = "Experience with primary urethral carcinoma from the blackfoot disease-endemic area of South Taiwan: Increased frequency of bulbomembranous adenocarcinoma?",
abstract = "Objectives: To describe and compare primary urethral carcinomas in South Taiwan with those in the USA and to explore the influence of chronic arsenic exposure. Methods: From 1988 to 2001, there were 21 pathologically proven primary urethral carcinomas diagnosed and treated at our hospital (14 males, 7 females). Seven of 14 male patients were chronically exposed to arsenic in drinking water for an average of 23 years. We compared our cases to three studies in the USA (80 males, 179 females), and analyzed the influence of chronic arsenic exposure by onset age, histology, staging, and outcome. Results: Male patients with localized tumors had better survival compared to those with advanced tumors (p = 0.0045 in males, p = 0.07 in females). In comparison to the three studies in the USA, there was an unusual higher frequency of bulbomembranous adenocarcinoma at our center (43 vs. 18{\%}, 2 and 0{\%}, respectively, p < 0.0001), particularly among those with chronic arsenic exposure (73 vs. 14{\%}, p = 0.031). Conclusions: In South Taiwan, there was a high frequency of bulbomembranous urethral adenocarcinoma, which might be associated with chronic arsenic exposure. Although the implications of such an observation are minimal owing to its rarity, it is worth exploring.",
author = "Tsai, {Yuh Shyan} and Yang, {Wen Horng} and Tong, {Yat Ching} and Lin, {Johnny S.N.} and Pan, {Chen Ching} and Tzai, {Tzong Shin}",
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T1 - Experience with primary urethral carcinoma from the blackfoot disease-endemic area of South Taiwan

T2 - Increased frequency of bulbomembranous adenocarcinoma?

AU - Tsai, Yuh Shyan

AU - Yang, Wen Horng

AU - Tong, Yat Ching

AU - Lin, Johnny S.N.

AU - Pan, Chen Ching

AU - Tzai, Tzong Shin

PY - 2005/4/1

Y1 - 2005/4/1

N2 - Objectives: To describe and compare primary urethral carcinomas in South Taiwan with those in the USA and to explore the influence of chronic arsenic exposure. Methods: From 1988 to 2001, there were 21 pathologically proven primary urethral carcinomas diagnosed and treated at our hospital (14 males, 7 females). Seven of 14 male patients were chronically exposed to arsenic in drinking water for an average of 23 years. We compared our cases to three studies in the USA (80 males, 179 females), and analyzed the influence of chronic arsenic exposure by onset age, histology, staging, and outcome. Results: Male patients with localized tumors had better survival compared to those with advanced tumors (p = 0.0045 in males, p = 0.07 in females). In comparison to the three studies in the USA, there was an unusual higher frequency of bulbomembranous adenocarcinoma at our center (43 vs. 18%, 2 and 0%, respectively, p < 0.0001), particularly among those with chronic arsenic exposure (73 vs. 14%, p = 0.031). Conclusions: In South Taiwan, there was a high frequency of bulbomembranous urethral adenocarcinoma, which might be associated with chronic arsenic exposure. Although the implications of such an observation are minimal owing to its rarity, it is worth exploring.

AB - Objectives: To describe and compare primary urethral carcinomas in South Taiwan with those in the USA and to explore the influence of chronic arsenic exposure. Methods: From 1988 to 2001, there were 21 pathologically proven primary urethral carcinomas diagnosed and treated at our hospital (14 males, 7 females). Seven of 14 male patients were chronically exposed to arsenic in drinking water for an average of 23 years. We compared our cases to three studies in the USA (80 males, 179 females), and analyzed the influence of chronic arsenic exposure by onset age, histology, staging, and outcome. Results: Male patients with localized tumors had better survival compared to those with advanced tumors (p = 0.0045 in males, p = 0.07 in females). In comparison to the three studies in the USA, there was an unusual higher frequency of bulbomembranous adenocarcinoma at our center (43 vs. 18%, 2 and 0%, respectively, p < 0.0001), particularly among those with chronic arsenic exposure (73 vs. 14%, p = 0.031). Conclusions: In South Taiwan, there was a high frequency of bulbomembranous urethral adenocarcinoma, which might be associated with chronic arsenic exposure. Although the implications of such an observation are minimal owing to its rarity, it is worth exploring.

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