Expression of vascular endothelial growth factor in primary superficial bladder cancer

Nan Haw Chow, Hsiao Sheng Liu, Shih Huang Chan, Hong Lin Cheng, Tzong Shin Tzai

研究成果: Article同行評審

36 引文 斯高帕斯(Scopus)


Background. Angiogenesis is of vital importance during the development and progression of solid tumors. This study was performed to test the clinical significance of vascular endothelial growth factor (VEGF) expression in primary superficial bladder cancer. Materials and Method. A cohort of 185 cases of pTa/pT1 transitional cell bladder cancer and six cases of normal urothelium were studied by immunohistochemistry. Expression of VEGF was correlated with biological indicators of bladder cancer and examined for their prognostic value. Results. Variable amounts of VEGF were detected in 35 cases (18.9%), with 17.9% and 20.3% in pTa and pT1 tumors, respectively. There was a positive association of VEGF expression with histological grading (p = 0.03). Otherwise, no apparent correlation was observed with remaining biopathological indicators (p > 0.1, respectively). Risk factors in predicting tumor recurrence were multiple tumors at diagnosis and lamina propria invasion (p < 0.05, respectively). Patients with multiple tumors also had a lower survival rate than those with a solitary tumor (p = 0.0008). However, expression of VEGF was not correlated with risk of tumor recurrence or patient survival (p > 0.1). Conclusions. Expression of VEGF is one of the characteristics of tumor dedifferentiation and may play a role in the development of a subset of superficial bladder cancer. Evaluation of VEGF expression dose not provide independent prognostic information for patients with superficial bladder cancer.

頁(從 - 到)4593-4597
期刊Anticancer research
發行號5 C
出版狀態Published - 1999 12月 1

All Science Journal Classification (ASJC) codes

  • 腫瘤科
  • 癌症研究


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