Expression patterns of erbB receptor family in normal urothelium and transitional cell carcinoma. An immunohistochemical study

Nan Haw Chow, Hsiao Sheng Liu, Hsiao Bai Yang, Shih Huang Chan, Ih Jen Su

研究成果: Article同行評審

58 引文 斯高帕斯(Scopus)

摘要

The class I tyrosine kinase growth-factor receptors include epidermal growth factor receptor (EGFR), ErbB2 (c-erbB-2, HER-2/neu), ErbB3 and ErbB4. To elucidate their role in the regulation of homeostasis and carcinogenesis, we examined the expression of the receptors in normal urothelium and in urothelial carcinoma by immunohistochemistry. EGFR was expressed in the basal cells of normal urothelium, while ErbB2, ErbB3 and ErbB4 were present mainly in the superficial layer. A distinct reciprocal distribution was observed between the EGFR and the remaining members of the subclass (P = 0.0001). Both BCL-2 protein and Ki-67 antigen (MIB-1) showed a strong positive association with EGFR (P = 0.002) and an inverse correlation with ErbB2, ErbB3 or ErbB4 (P = 0.0004, 0.0000, and 0.001, respectively). With regard to carcinoma, there was no important relationship between receptor overexpression and tumour grading (P > 0.1), while only EGFR overexpression was correlated with muscular invasion (P = 0.02). Coexpression of EGFR-ErbB3 and ErbB3-ErbB4 was more often detected in high-grade tumours and correlated with the extent of tumour invasion. Our data indicate that class I receptors are differentially expressed in normal urothelium in vivo, but an orchestrated expression pattern does not exist during tumorigenesis.

原文English
頁(從 - 到)461-466
頁數6
期刊Virchows Archiv
430
發行號6
DOIs
出版狀態Published - 1997

All Science Journal Classification (ASJC) codes

  • 病理學與法醫學
  • 分子生物學
  • 細胞生物學

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