Extended lamivudine treatment in patients with chronic hepatitis B enhances hepatitis B e antigen seroconversion rates: Results after 3 years of therapy

Nancy W.Y. Leung, Ching Lung Lai, Ting Tsung Chang, Richard Guan, Chuan Mo Lee, Keng Yeen Ng, Seng Gee Lim, Pui Chee Wu, Julie C. Dent, Sally Edmundson, Lynn D. Condreay, Rong Nan Chien, Steven Tsang, Man Fung Yuen, Wai Man Wong, Ai Wen Kao, Chiu Jung Chen, Khoon Beng Chuah, Han Seong Ng

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620 引文 斯高帕斯(Scopus)

摘要

A study in Chinese patients with chronic hepatitis B showed that treatment with lamivudine for 1 year significantly improves liver histology and enhances hepatitis B e antigen (HBeAg) seroconversion compared with placebo. Fifty-eight patients from this 1-year study have received long-term treatment with lamivudine 100 mg; the outcome of 3 years of lamivudine is reported here: Before treatment, all patients had detectable HBeAg. HBeAg seroconversion (HBeAg-negative, anti-HBe-positive), hepatitis B virus (HBV)-DNA suppression, alanine transaminase (ALT) normalization, emergence of YMDD variant HBV, liver histology, and long-term safety were assessed. After 3 years of continuous treatment with lamivudine 100 mg daily, 40% (23 of 58) of patients achieved HBeAg seroconversion. In patients with baseline serum ALT >2× upper limit of normal (ULN), the rate of HBeAg seroconversion was 65% (17 of 26). Median serum HBV-DNA concentrations Were below the level of detection, and median ALT concentrations were within the normal range throughout 3 years of treatment. YMDD variant HBV emerged in 33 of 58 (57%) patients during the 3 years, of whom 9 (27%) achieved HBeAg seroconversion (6 after emergence of YMDD variant HBV). ALT levels and histologic scores after emergence of YMDD variant HBV did not show major deterioration. Lamivudine was well tolerated during 3 years of therapy. In conclusion, these data in Chinese patients with chronic hepatitis B show enhanced seroconversion rates with extended lamivudine treatment. Up to two thirds of patients with moderately elevated pretreatment ALT achieved HBeAg seroconversion after 3 years of therapy.

原文English
頁(從 - 到)1527-1532
頁數6
期刊Hepatology
33
發行號6
DOIs
出版狀態Published - 2001

All Science Journal Classification (ASJC) codes

  • 肝病

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