Factors contributing to the disturbance of coagulation and fibrinolysis in dengue virus infection

Yung Chun Chuang; Yee Shin Lin; Ching Chuan Liu; Hsiao Sheng Liu; Shu Hsing Liao; Ming Der Shi; Huan Yao Lei; Trai Ming Yeh

doi:10.1016/j.jfma.2012.10.013

Factors contributing to the disturbance of coagulation and fibrinolysis in dengue virus infection

Yung Chun Chuang, Yee Shin Lin, Ching Chuan Liu, Hsiao Sheng Liu, Shu Hsing Liao, Ming Der Shi, Huan Yao Lei, Trai Ming Yeh

研究成果: Review article › 同行評審

36 引文斯高帕斯（Scopus）

摘要

Hemorrhage is one of the hallmarks of dengue hemorrhagic fever. However, the mechanisms that cause hemorrhage are unclear. In this review we focus on the possible factors that may be involved in the disturbance of coagulation and fibrinolysis during dengue virus (DENV) infection. Factors such as autoantibodies and cytokines induced by DENV infection as well as hemostatic molecules expressed on DENV-infected cells, and DENV viral proteins may all contribute to the defect of hemostasis during DENV infection. It is the combination of these viral and host factors that may tilt the balance of coagulation and fibrinolysis toward bleeding in dengue patients.

原文	English
頁（從 - 到）	12-17
頁數	6
期刊	Journal of the Formosan Medical Association
卷	112
發行號	1
DOIs	https://doi.org/10.1016/j.jfma.2012.10.013
出版狀態	Published - 2013 1月

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10.1016/j.jfma.2012.10.013

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abstract = "Hemorrhage is one of the hallmarks of dengue hemorrhagic fever. However, the mechanisms that cause hemorrhage are unclear. In this review we focus on the possible factors that may be involved in the disturbance of coagulation and fibrinolysis during dengue virus (DENV) infection. Factors such as autoantibodies and cytokines induced by DENV infection as well as hemostatic molecules expressed on DENV-infected cells, and DENV viral proteins may all contribute to the defect of hemostasis during DENV infection. It is the combination of these viral and host factors that may tilt the balance of coagulation and fibrinolysis toward bleeding in dengue patients.",

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AU - Chuang, Yung Chun

AU - Lin, Yee Shin

AU - Liu, Ching Chuan

AU - Liu, Hsiao Sheng

AU - Liao, Shu Hsing

AU - Shi, Ming Der

AU - Lei, Huan Yao

AU - Yeh, Trai Ming

PY - 2013/1

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N2 - Hemorrhage is one of the hallmarks of dengue hemorrhagic fever. However, the mechanisms that cause hemorrhage are unclear. In this review we focus on the possible factors that may be involved in the disturbance of coagulation and fibrinolysis during dengue virus (DENV) infection. Factors such as autoantibodies and cytokines induced by DENV infection as well as hemostatic molecules expressed on DENV-infected cells, and DENV viral proteins may all contribute to the defect of hemostasis during DENV infection. It is the combination of these viral and host factors that may tilt the balance of coagulation and fibrinolysis toward bleeding in dengue patients.

AB - Hemorrhage is one of the hallmarks of dengue hemorrhagic fever. However, the mechanisms that cause hemorrhage are unclear. In this review we focus on the possible factors that may be involved in the disturbance of coagulation and fibrinolysis during dengue virus (DENV) infection. Factors such as autoantibodies and cytokines induced by DENV infection as well as hemostatic molecules expressed on DENV-infected cells, and DENV viral proteins may all contribute to the defect of hemostasis during DENV infection. It is the combination of these viral and host factors that may tilt the balance of coagulation and fibrinolysis toward bleeding in dengue patients.

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Factors contributing to the disturbance of coagulation and fibrinolysis in dengue virus infection

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