Factors contributing to the disturbance of coagulation and fibrinolysis in dengue virus infection

Yung Chun Chuang, Yee-Shin Lin, Ching-Chuan Liu, Hsiao-Sheng Liu, Shu Hsing Liao, Ming Der Shi, Huan Yao Lei, Trai-Ming Yeh

研究成果: Review article

19 引文 (Scopus)

摘要

Hemorrhage is one of the hallmarks of dengue hemorrhagic fever. However, the mechanisms that cause hemorrhage are unclear. In this review we focus on the possible factors that may be involved in the disturbance of coagulation and fibrinolysis during dengue virus (DENV) infection. Factors such as autoantibodies and cytokines induced by DENV infection as well as hemostatic molecules expressed on DENV-infected cells, and DENV viral proteins may all contribute to the defect of hemostasis during DENV infection. It is the combination of these viral and host factors that may tilt the balance of coagulation and fibrinolysis toward bleeding in dengue patients.

原文English
頁(從 - 到)12-17
頁數6
期刊Journal of the Formosan Medical Association
112
發行號1
DOIs
出版狀態Published - 2013 一月 1

指紋

Dengue Virus
Fibrinolysis
Virus Diseases
Hemorrhage
Severe Dengue
Dengue
Viral Proteins
Hemostatics
Hemostasis
Autoantibodies
Cytokines

All Science Journal Classification (ASJC) codes

  • Medicine(all)

引用此文

Chuang, Yung Chun ; Lin, Yee-Shin ; Liu, Ching-Chuan ; Liu, Hsiao-Sheng ; Liao, Shu Hsing ; Shi, Ming Der ; Lei, Huan Yao ; Yeh, Trai-Ming. / Factors contributing to the disturbance of coagulation and fibrinolysis in dengue virus infection. 於: Journal of the Formosan Medical Association. 2013 ; 卷 112, 編號 1. 頁 12-17.
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Factors contributing to the disturbance of coagulation and fibrinolysis in dengue virus infection. / Chuang, Yung Chun; Lin, Yee-Shin; Liu, Ching-Chuan; Liu, Hsiao-Sheng; Liao, Shu Hsing; Shi, Ming Der; Lei, Huan Yao; Yeh, Trai-Ming.

於: Journal of the Formosan Medical Association, 卷 112, 編號 1, 01.01.2013, p. 12-17.

研究成果: Review article

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AU - Chuang, Yung Chun

AU - Lin, Yee-Shin

AU - Liu, Ching-Chuan

AU - Liu, Hsiao-Sheng

AU - Liao, Shu Hsing

AU - Shi, Ming Der

AU - Lei, Huan Yao

AU - Yeh, Trai-Ming

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AB - Hemorrhage is one of the hallmarks of dengue hemorrhagic fever. However, the mechanisms that cause hemorrhage are unclear. In this review we focus on the possible factors that may be involved in the disturbance of coagulation and fibrinolysis during dengue virus (DENV) infection. Factors such as autoantibodies and cytokines induced by DENV infection as well as hemostatic molecules expressed on DENV-infected cells, and DENV viral proteins may all contribute to the defect of hemostasis during DENV infection. It is the combination of these viral and host factors that may tilt the balance of coagulation and fibrinolysis toward bleeding in dengue patients.

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