Factors influencing treatment outcome in patients with gastroesophageal reflux disease: Outcome of a prospective pragmatic trial in Asian patients

Khean L. Goh, Kee D. Choi, Myung Gyu Choi, Tsai Yuan Hsieh, Hwoon Yong Jung, Han Chung Lien, Jayaram Menon, Steven Mesenas, Hyojin Park, Bor Shyang Sheu, Justin C.Y. Wu

研究成果: Article同行評審

7 引文 斯高帕斯(Scopus)

摘要

Background: Predicting response to proton pump inhibitor (PPI) treatment can aid the effective management of gastroesophageal reflux disease (GERD). The aim was to investigate the predictors of symptomatic response to pantoprazole in Asian patients with GERD; the first study of its kind in Asian patients. Methods: Asian patients with GERD symptoms (N = 209) received pantoprazole 40 mg daily for 8 weeks in a multinational, prospective, open-label study. Response was assessed using ReQuest™. Baseline and demographic factors were examined using logistic regression to determine if they were related to treatment response. Results: Response rates were 44.3% (Week 4) and 63.6% (Week 8) in Asian patients versus 60.7% (P < 0.001) and 72.2% (P = 0.010) for the rest of the world. Higher response rates at 8 weeks occurred in patients with erosive reflux disease (ERD; 71.3%) versus those with non-erosive reflux disease (NERD) at baseline (48.5%). The presence of ERD (P = 0.0143) and lower ReQuest™-GI scores at baseline (P = 0.0222) were associated with response. Improvements in quality of life (QoL) and anxiety and depression at 4 and 8 weeks were associated with treatment response (both P < 0.0001). Patient satisfaction correlated with treatment response (P < 0.0001), and improvement in anxiety and depression (P < 0.0001) and QoL (P < 0.0001). Conclusions: Asian patients with GERD, especially those with NERD, may have lower response rates to PPIs than Western populations. ERD and less severe gastrointestinal symptoms may help to predict symptomatic responses to PPIs in Asian patients. Trial Registration: ClinicalTrial.gov identifier: NCT00312806.

原文English
文章編號156
期刊BMC Gastroenterology
14
發行號1
DOIs
出版狀態Published - 2014 九月 9

All Science Journal Classification (ASJC) codes

  • 消化內科

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