Fatal coxsackievirus B infection in early infancy characterized by fulminant hepatitis

S. M. Wang, C. C. Liu, Y. J. Yang, H. B. Yang, C. H. Lin, J. R. Wang

研究成果: Article

37 引文 (Scopus)

摘要

Objectives: to clarify the major features of fatal coxsackievirus B infection characterized by fulminant hepatitis in early infancy. Methods: clinical manifestations and laboratory investigations concerning five consecutive young infants with overwhelming coxsackievirus B fulminant hepatitis between 1994 and 1997 were retrospectively reviewed. Aetiological diagnosis was made by viral cultures and confirmed by a neutralization test with a type-specific antiserum. Results: all five had a deteriorating clinical course of severe hepatitis complicated by disseminated intravascular coagulopathy (DIC). Coxsackievirus B1 infection was established in four patients and coxsackievirus B3 in one. The pathological findings of the two cases illustrated extensive hepatocellular necrosis. Fulminant hepatitis can occur as a leading presentation of disseminated coxsackievirus B infections and dominant the clinical features in neonates and young infants. Conclusions: the liver was the target organ of fatal coxsackievirus B infection in our patients. Hepatic involvement progressed rapidly to jaundice and coagulopathy, and was considered to be indicative of poor prognosis. Coxsackievirus B hepatitis may be serious in early infancy.

原文English
頁(從 - 到)270-273
頁數4
期刊Journal of Infection
37
發行號3
DOIs
出版狀態Published - 1998 一月 1

指紋

Coxsackievirus Infections
Human Enterovirus B
Hepatitis
Neutralization Tests
Enterovirus
Liver
Jaundice
Immune Sera
Necrosis
Newborn Infant

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases

引用此文

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abstract = "Objectives: to clarify the major features of fatal coxsackievirus B infection characterized by fulminant hepatitis in early infancy. Methods: clinical manifestations and laboratory investigations concerning five consecutive young infants with overwhelming coxsackievirus B fulminant hepatitis between 1994 and 1997 were retrospectively reviewed. Aetiological diagnosis was made by viral cultures and confirmed by a neutralization test with a type-specific antiserum. Results: all five had a deteriorating clinical course of severe hepatitis complicated by disseminated intravascular coagulopathy (DIC). Coxsackievirus B1 infection was established in four patients and coxsackievirus B3 in one. The pathological findings of the two cases illustrated extensive hepatocellular necrosis. Fulminant hepatitis can occur as a leading presentation of disseminated coxsackievirus B infections and dominant the clinical features in neonates and young infants. Conclusions: the liver was the target organ of fatal coxsackievirus B infection in our patients. Hepatic involvement progressed rapidly to jaundice and coagulopathy, and was considered to be indicative of poor prognosis. Coxsackievirus B hepatitis may be serious in early infancy.",
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AU - Wang, S. M.

AU - Liu, C. C.

AU - Yang, Y. J.

AU - Yang, H. B.

AU - Lin, C. H.

AU - Wang, J. R.

PY - 1998/1/1

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N2 - Objectives: to clarify the major features of fatal coxsackievirus B infection characterized by fulminant hepatitis in early infancy. Methods: clinical manifestations and laboratory investigations concerning five consecutive young infants with overwhelming coxsackievirus B fulminant hepatitis between 1994 and 1997 were retrospectively reviewed. Aetiological diagnosis was made by viral cultures and confirmed by a neutralization test with a type-specific antiserum. Results: all five had a deteriorating clinical course of severe hepatitis complicated by disseminated intravascular coagulopathy (DIC). Coxsackievirus B1 infection was established in four patients and coxsackievirus B3 in one. The pathological findings of the two cases illustrated extensive hepatocellular necrosis. Fulminant hepatitis can occur as a leading presentation of disseminated coxsackievirus B infections and dominant the clinical features in neonates and young infants. Conclusions: the liver was the target organ of fatal coxsackievirus B infection in our patients. Hepatic involvement progressed rapidly to jaundice and coagulopathy, and was considered to be indicative of poor prognosis. Coxsackievirus B hepatitis may be serious in early infancy.

AB - Objectives: to clarify the major features of fatal coxsackievirus B infection characterized by fulminant hepatitis in early infancy. Methods: clinical manifestations and laboratory investigations concerning five consecutive young infants with overwhelming coxsackievirus B fulminant hepatitis between 1994 and 1997 were retrospectively reviewed. Aetiological diagnosis was made by viral cultures and confirmed by a neutralization test with a type-specific antiserum. Results: all five had a deteriorating clinical course of severe hepatitis complicated by disseminated intravascular coagulopathy (DIC). Coxsackievirus B1 infection was established in four patients and coxsackievirus B3 in one. The pathological findings of the two cases illustrated extensive hepatocellular necrosis. Fulminant hepatitis can occur as a leading presentation of disseminated coxsackievirus B infections and dominant the clinical features in neonates and young infants. Conclusions: the liver was the target organ of fatal coxsackievirus B infection in our patients. Hepatic involvement progressed rapidly to jaundice and coagulopathy, and was considered to be indicative of poor prognosis. Coxsackievirus B hepatitis may be serious in early infancy.

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