Fetuin-A as a predicator of sarcopenic left ventricular dysfunction

Wei Ting Chang, Wei Chuan Tsai, Chih Hsing Wu, Yen Wei Lee, Yun Lin Tai, Yi Heng Li, Liang Miin Tsai, Jyh Hong Chen, Ping Yen Liu

研究成果: Article

5 引文 (Scopus)

摘要

Sarcopenia is an aging condition involving low muscle mass and function. Fetuin-A (FetA) appears to be a factor for body composition remodeling. We hypothesized that age increases FetA levels and deteriorates the myocardial function by affecting diastolic function, especially in people with sarcopenia. We enrolled 541 asymptomatic elderly (≥65 years) patients. Compared with non-sarcopenic population, FetA levels were significantly elevated in the ninety-two (17%) patients (79 ± 6 years; male: 34.7%) diagnosed with sarcopenia (621.1 ± 140.7 vs. 697.3 ± 179.6 μg/ml, < 0.001). Sarcopenic left ventricular dysfunction (S-LVD) was defined by the coexistence of sarcopenia and systolic impairment (LVEF < 50%) and 23 (4.3%) of them met the criteria. Patients with S-LVD showed relatively reduced systolic heart function, higher end-diastolic pressure and a higher FetA level (all p < 0.001) than did those with sarcopenia but without LV dysfunction (S-NLVD). Conversely, in the group without sarcopenia, FetA levels were similar regardless of systolic function. Multivariable logistic regression showed that older age, impaired diastolic function, and higher FetA levels were significantly associated with S-LVD. In conclusion, we found that FetA was significantly higher in elderly patients with sarcopenia, which was associated with impaired diastolic and systolic functions.

原文English
文章編號12078
期刊Scientific reports
5
DOIs
出版狀態Published - 2015 七月 10

指紋

alpha-2-HS-Glycoprotein
Sarcopenia
Left Ventricular Dysfunction
Body Composition
Logistic Models
Blood Pressure
Muscles

All Science Journal Classification (ASJC) codes

  • General

引用此文

Chang, Wei Ting ; Tsai, Wei Chuan ; Wu, Chih Hsing ; Lee, Yen Wei ; Tai, Yun Lin ; Li, Yi Heng ; Tsai, Liang Miin ; Chen, Jyh Hong ; Liu, Ping Yen. / Fetuin-A as a predicator of sarcopenic left ventricular dysfunction. 於: Scientific reports. 2015 ; 卷 5.
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abstract = "Sarcopenia is an aging condition involving low muscle mass and function. Fetuin-A (FetA) appears to be a factor for body composition remodeling. We hypothesized that age increases FetA levels and deteriorates the myocardial function by affecting diastolic function, especially in people with sarcopenia. We enrolled 541 asymptomatic elderly (≥65 years) patients. Compared with non-sarcopenic population, FetA levels were significantly elevated in the ninety-two (17{\%}) patients (79 ± 6 years; male: 34.7{\%}) diagnosed with sarcopenia (621.1 ± 140.7 vs. 697.3 ± 179.6 μg/ml, < 0.001). Sarcopenic left ventricular dysfunction (S-LVD) was defined by the coexistence of sarcopenia and systolic impairment (LVEF < 50{\%}) and 23 (4.3{\%}) of them met the criteria. Patients with S-LVD showed relatively reduced systolic heart function, higher end-diastolic pressure and a higher FetA level (all p < 0.001) than did those with sarcopenia but without LV dysfunction (S-NLVD). Conversely, in the group without sarcopenia, FetA levels were similar regardless of systolic function. Multivariable logistic regression showed that older age, impaired diastolic function, and higher FetA levels were significantly associated with S-LVD. In conclusion, we found that FetA was significantly higher in elderly patients with sarcopenia, which was associated with impaired diastolic and systolic functions.",
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Fetuin-A as a predicator of sarcopenic left ventricular dysfunction. / Chang, Wei Ting; Tsai, Wei Chuan; Wu, Chih Hsing; Lee, Yen Wei; Tai, Yun Lin; Li, Yi Heng; Tsai, Liang Miin; Chen, Jyh Hong; Liu, Ping Yen.

於: Scientific reports, 卷 5, 12078, 10.07.2015.

研究成果: Article

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AU - Tsai, Wei Chuan

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AU - Li, Yi Heng

AU - Tsai, Liang Miin

AU - Chen, Jyh Hong

AU - Liu, Ping Yen

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AB - Sarcopenia is an aging condition involving low muscle mass and function. Fetuin-A (FetA) appears to be a factor for body composition remodeling. We hypothesized that age increases FetA levels and deteriorates the myocardial function by affecting diastolic function, especially in people with sarcopenia. We enrolled 541 asymptomatic elderly (≥65 years) patients. Compared with non-sarcopenic population, FetA levels were significantly elevated in the ninety-two (17%) patients (79 ± 6 years; male: 34.7%) diagnosed with sarcopenia (621.1 ± 140.7 vs. 697.3 ± 179.6 μg/ml, < 0.001). Sarcopenic left ventricular dysfunction (S-LVD) was defined by the coexistence of sarcopenia and systolic impairment (LVEF < 50%) and 23 (4.3%) of them met the criteria. Patients with S-LVD showed relatively reduced systolic heart function, higher end-diastolic pressure and a higher FetA level (all p < 0.001) than did those with sarcopenia but without LV dysfunction (S-NLVD). Conversely, in the group without sarcopenia, FetA levels were similar regardless of systolic function. Multivariable logistic regression showed that older age, impaired diastolic function, and higher FetA levels were significantly associated with S-LVD. In conclusion, we found that FetA was significantly higher in elderly patients with sarcopenia, which was associated with impaired diastolic and systolic functions.

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