Finite element modeling of hyper-viscoelasticity of peripheral nerve ultrastructures

Cheng Tao Chang, Yu Hsing Chen, Chou Ching K. Lin, Ming Shaung Ju

研究成果: Article同行評審

13 引文 斯高帕斯(Scopus)

摘要

The mechanical characteristics of ultrastructures of rat sciatic nerves were investigated through animal experiments and finite element analyses. A custom-designed dynamic testing apparatus was used to conduct in vitro transverse compression experiments on the nerves. The optical coherence tomography (OCT) was utilized to record the cross-sectional images of nerve during the dynamic testing. Two-dimensional finite element models of the nerves were built based on their OCT images. A hyper-viscoelastic model was employed to describe the elastic and stress relaxation response of each ultrastructure of the nerve, namely the endoneurium, the perineurium and the epineurium. The first-order Ogden model was employed to describe the elasticity of each ultrastructure and a generalized Maxwell model for the relaxation. The inverse finite element analysis was used to estimate the material parameters of the ultrastructures. The results show the instantaneous shear modulus of the ultrastructures in decreasing order is perineurium, endoneurium, and epineurium. The FE model combined with the first-order Ogden model and the second-order Prony series is good enough for describing the compress-and-hold response of the nerve ultrastructures. The integration of OCT and the nonlinear finite element modeling may be applicable to study the viscoelasticity of peripheral nerve down to the ultrastructural level.

原文English
頁(從 - 到)1982-1987
頁數6
期刊Journal of Biomechanics
48
發行號10
DOIs
出版狀態Published - 2015 七月 16

All Science Journal Classification (ASJC) codes

  • 生物物理學
  • 生物醫學工程
  • 骨科和運動醫學
  • 復健

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