Follicular dendritic cell sarcoma of the colon mimicking stromal tumour

K. C. Chang, Y. T. Jin, F. F. Chen, I. J. Su

研究成果: Article同行評審

41 引文 斯高帕斯(Scopus)


Aims: Follicular dendritic cell tumours are very rare neoplasms that often occur in lymph nodes. We report here a case in the Colon, a hitherto unreported site, in a 37-year-old female. The differentiation from gastrointestinal stromal tumour is emphasized. Methods and results: The tumour was tan, elastic and solid with surface ulceration. Microscopically, it was composed of oval to spindle tumour cells with syncytial cytoplasm arranged in fascicular and whorled patterns. There were many infiltrating lymphocytes. The histological appearance resembled gastrointestinal stromal tumour, thymoma or meningioma. Distinct from the stromal tumour, the lymph node was also involved by the tumour. Immunohistochemically, the tumour cells were positive for CD21, CD35 and CD68, but negative for cytokeratin, CD34, smooth muscle actin, desmin, S100 protein, epithelial membrane antigen, leukocyte common antigen, HMB-45 and c-kit. In-situ hybridization study was negative for Epstein-Barr virus RNA sequences. Ultrastructurally, the tumour cells possessed cytoplasmic processes joined by desmosomes. Conclusions: This entity should be considered in the list of differential diagnoses for gastrointestinal stromal tumour. The lymph node metastasis and immunohistochemical features are of value for identification of this rare neoplasm.

頁(從 - 到)25-29
出版狀態Published - 2001

All Science Journal Classification (ASJC) codes

  • 病理學與法醫學
  • 組織學


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