Force-mediated dissociation of proteoglycan aggregate in articular cartilage

Xuhui Liu, Jian Q. Sun, Michael H. Heggeness, Ming Long Yeh, Zong Ping Luo

研究成果: Article

4 引文 斯高帕斯(Scopus)

摘要

Proteoglycan aggregate is the primary component in articular cartilage responsible for resisting compressive loading. It consists of a core molecule of hyaluronan and a number of side chains of aggrecan bound to hyaluronan non-covalently. The loss of aggrecan from articular cartilage is considered to be a major factor in the development of osteoarthritis. Though enzymatic digestion of aggrecan is believed to be responsible for the release of aggrecan from osteoarthritic cartilage, other mechanisms, such as direct force-mediated detachment of aggrecan from hyaluronan may also be involved. In this study, the rupture force of the single bond between hyaluronan and aggrecan in articular cartilage was directly quantified using experimental measurement and Monte Carlo simulation. Low rupture force of this bond, as determined in this study suggested a possible direct force-mediated detachment of aggrecan from proteoglycan aggregate in osteoarthritic cartilage.

原文English
頁(從 - 到)183-190
頁數8
期刊Biorheology
43
發行號3-4
出版狀態Published - 2006 八月 18

All Science Journal Classification (ASJC) codes

  • Physiology
  • Physiology (medical)

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    Liu, X., Sun, J. Q., Heggeness, M. H., Yeh, M. L., & Luo, Z. P. (2006). Force-mediated dissociation of proteoglycan aggregate in articular cartilage. Biorheology, 43(3-4), 183-190.