Four new 6-nor-5(6→7)abeo-abietane type diterpenes and antitumoral cytotoxic diterpene constituents from the bark of Taiwania cryptomerioides

Chi I. Chang, Jang-Yang Chang, Ching Chuan Kuo, Wen Yu Pan, Yueh Hsiung Kuo

研究成果: Article

68 引文 (Scopus)

摘要

Four new 6-nor-5(6→7)abeo-abietane type diterpenes designated as taiwaniaquinone G, taiwaniaquinone H, taiwaniaquinol E and taiwaniaquinol F and eight known diterpenes, taiwaniaquinones A (5), D (6), E, F (8), and taiwaniaquinols A (9), B, C (11), D (12) were isolated from the bark of Taiwania cryptomerioides. Their structures were elucidated on the basis of spectroscopic studies. These twelve diterpenes were evaluated for in vitro anti-tumoral cytotoxic activity. The result demonstrated that compounds 5, 6, 8, 9, 11, and 12 bearing an aldehyde group possessed potent cytotoxic activity against KB epidermoid carcinoma cancer cell lines with IC50 values of 6.9, 7.2, 4.4, 8.3, 8.1, and 3.5 μM, respectively.

原文English
頁(從 - 到)72-76
頁數5
期刊Planta Medica
71
發行號1
DOIs
出版狀態Published - 2005 一月 1

指紋

Abietane Diterpenes
Diterpenes
Bearings (structural)
Aldehydes
Inhibitory Concentration 50
Squamous Cell Carcinoma
Cells
Cell Line
Neoplasms

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

引用此文

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abstract = "Four new 6-nor-5(6→7)abeo-abietane type diterpenes designated as taiwaniaquinone G, taiwaniaquinone H, taiwaniaquinol E and taiwaniaquinol F and eight known diterpenes, taiwaniaquinones A (5), D (6), E, F (8), and taiwaniaquinols A (9), B, C (11), D (12) were isolated from the bark of Taiwania cryptomerioides. Their structures were elucidated on the basis of spectroscopic studies. These twelve diterpenes were evaluated for in vitro anti-tumoral cytotoxic activity. The result demonstrated that compounds 5, 6, 8, 9, 11, and 12 bearing an aldehyde group possessed potent cytotoxic activity against KB epidermoid carcinoma cancer cell lines with IC50 values of 6.9, 7.2, 4.4, 8.3, 8.1, and 3.5 μM, respectively.",
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Four new 6-nor-5(6→7)abeo-abietane type diterpenes and antitumoral cytotoxic diterpene constituents from the bark of Taiwania cryptomerioides. / Chang, Chi I.; Chang, Jang-Yang; Kuo, Ching Chuan; Pan, Wen Yu; Kuo, Yueh Hsiung.

於: Planta Medica, 卷 71, 編號 1, 01.01.2005, p. 72-76.

研究成果: Article

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AU - Pan, Wen Yu

AU - Kuo, Yueh Hsiung

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