Frequencies of fetal nucleated red blood cells in maternal blood during different stages of gestation

研究成果: Article

23 引文 斯高帕斯(Scopus)

摘要

Nucleated red blood cells (NRBCs) isolated by a triple density gradient from 100 ml peripheral blood samples of 100 pregnant women and 30 women post-partum were subjected to morphological analysis and PCR quantitation. The number of NRBCs steadily increased from 5.3 (frequency: 2.4 x 10-7) in early gestation to 98.2 (frequency: 4.2 x 10-6) near term. The number of male cells increased from 6 (frequency: 2.7 x 10-7) in early gestation to a peak of 31 (frequency: 1.48 x 10-6) in the second trimester, and slightly decreased to 27 (frequency: 1.31 x 10-6) near term. Both NRBCs and male fetal cells rapidly disappeared after delivery. The result implies that a significant proportion of NRBCs in maternal blood are of fetal origin before 24 weeks of gestation while in late gestation the majority of NRBCs may be of maternal origin.

原文English
頁(從 - 到)375-379
頁數5
期刊Fetal Diagnosis and Therapy
13
發行號6
DOIs
出版狀態Published - 1998 十二月 1

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Embryology
  • Radiology Nuclear Medicine and imaging
  • Obstetrics and Gynaecology

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