Function and regulation of let-7 family microRNAs

Jen Liang Su, Pai Sheng Chen, Gunnar Johansson

研究成果: Review article同行評審

70 引文 斯高帕斯(Scopus)

摘要

MicroRNAs (miRNAs) are a group of small noncoding RNAs capable of regulating specific gene expression. Let-7 miRNA was first discovered in Caenorhabditis elegans and it is highly conserved in human tissues. The human let- 7 family of miRNA contains 12 members of miRNA. Today, these members have become the most studied miRNAs and they have attracted attention of researchers in various fields, such as development, stem cell biology, aging, and metabolism. Furthermore, there is a large body of evidence linking the loss of let-7 expression and the development of poorly differentiated, aggressive cancers. In addition to the canonical biogenesis pathway, let-7 has been found to be regulated by protein factors, such as RNA binding proteins previously identified as regulators of protein-coding mRNAs. Moreover, the direct interaction between miRNAs has recently been identified as a novel pathway to control let-7 expression. In this review, we discuss the multifaceted roles of let-7 and provide an overview of its regulation at multiple levels.

原文English
頁(從 - 到)34-39
頁數6
期刊MicroRNA (Shāriqah, United Arab Emirates)
1
發行號1
DOIs
出版狀態Published - 2012

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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