Functional implication of the interaction between egf receptor and C-SRC

Tzeng Horng Leu, Ming Chei Maa

研究成果: Review article同行評審

61 引文 斯高帕斯(Scopus)


EGF receptor (EGFR) and c-Src are the prototypes that individually represent the receptor and nonreceptor tyrosine kinases respectively. Accumulated evidence reveals the association between EGF-activated EGFR and c-Src that leads to activation of both kinases. Importantly, their mutual interaction is required for many EGFR-mediated cellular functions including proliferation, migration, survival and EGFR endocytosis. Interestingly, activation of c-Src and its association with transactivated EGFR is also observed in cells stimulated with non-EGF agonists. This review will not only discuss the structure, function and regulation of these two tyrosine kinases, but also will summarize our current knowledge of the molecular mechanisms depicting the cellular events that require their participation.

頁(從 - 到)s28-s38
期刊Frontiers in Bioscience
出版狀態Published - 2003

All Science Journal Classification (ASJC) codes

  • 生物化學、遺傳與分子生物學 (全部)
  • 免疫學與微生物學 (全部)


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