Functions of DDR1 in epithelial cell differentiation

研究成果: Chapter

摘要

Epithelial cell differentiation is a critical element in the development and progression of disease, and the assembly of adherens junctions is the limiting step that determines epithelial cell differentiation. Signals from the microenvironment, including growth factors, cytokines, or the extracellular matrix, all have a significant impact on the assembly of adherens junctions. An increase of collagen deposition is no longer considered to be a consequence, but rather an inducer of disease progression, as the signal from integrin a2β1 mediates epithelial dedifferentiation via disturbing the stability of adherens junctions. However, as a collagen receptor, discoidin domain receptor 1 (DDR1) exhibits counter effects in regulating epithelial cell differentiation. This is due to the ability of DDR1 to maintain the stability of adherens junctions. The evidence and mechanisms whereby DDR1 regulates epithelial cell differentiation will all be addressed in this chapter.

原文English
主出版物標題Discoidin Domain Receptors in Health and Disease
發行者Springer New York
頁面239-258
頁數20
ISBN(電子)9781493963836
ISBN(列印)9781493963812
DOIs
出版狀態Published - 2016 1月 1

All Science Journal Classification (ASJC) codes

  • 一般醫學
  • 一般免疫學和微生物學
  • 一般生物化學,遺傳學和分子生物學

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