Further characterization of a potent immunogen and the chromosomal gene encoding it in the lyme disease agent, Borrelia burgdorferi

G. C. Perng, R. B. LeFebvre, R. C. Johnson

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21 引文 斯高帕斯(Scopus)

摘要

Further characterization of a previously reported 83-kDa antigen of Borrelia burgdorferi and the gene encoding it is reported. The DNA sequence of the gene and the amino acid sequence of the protein were determined. On the basis of the amino acid content, the actual size of the antigen was determined to be 79.8 kDa, rather than 83 kDa as previously reported. The expression of the antigen in several representative North American and European B. burgdorferi isolates was demonstrated. The conservation of the gene within the species was demonstrated by DNA hybridization of a labeled gene probe to several North American and European B. burgdorferi isolates. Of other Borrelia spp. assayed (B. hermsii, B. coriaceae, B. duttonii, and B. anserina), only B. anserina, a poultry pathogen, hybridized to the gene probe and expressed the 79.8-kDa antigen.

原文English
頁(從 - 到)2070-2074
頁數5
期刊Infection and Immunity
59
發行號6
出版狀態Published - 1991 一月 1

All Science Journal Classification (ASJC) codes

  • 寄生物學
  • 微生物學
  • 免疫學
  • 傳染性疾病

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