Fusidic acid for the treatment of bone and joint infections caused by meticillin-resistant Staphylococcus aureus

Jiun-Ling Wang, Hung Jen Tang, Pang Hsin Hsieh, Fang Yao Chiu, Yen Hsu Chen, Ming Chau Chang, Ching Tai Huang, Chang Pan Liu, Yeu Jun Lau, Kao Pin Hwang, Wen-Chien Ko, Chen Ti Wang, Cheng Yi Liu, Chien Lin Liu, Po Ren Hsueh

研究成果: Short survey

24 引文 斯高帕斯(Scopus)

摘要

There is a lack of surveillance data on resistance to fusidic acid (FA) in Asia, and no reviews of FA usage for the treatment of orthopaedic infections have been conducted since the year 2000. In this study, we present a systemic literature review of FA resistance in Asia and the clinical use of FA for the treatment of bone and joint infections (BJIs). The in vitro activity of FA against meticillin-resistant Staphylococcus aureus (MRSA) isolates remains good, with low (<10%) resistance rates in most Asian countries. FA in Asia appears to be a better oral anti-MRSA agent than trimethoprim/sulfamethoxazole and clindamycin. More than 80 cases of FA use for BJI have been reported since 2000 and the recurrence or failure rate is <10%. There is much evidence supporting the use of FA in combination with other antibiotics (e.g. rifampicin) as an oral treatment following intravenous glycopeptide treatment for BJIs.

原文English
頁(從 - 到)103-107
頁數5
期刊International journal of antimicrobial agents
40
發行號2
DOIs
出版狀態Published - 2012 一月 1

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases
  • Pharmacology (medical)

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    Wang, J-L., Tang, H. J., Hsieh, P. H., Chiu, F. Y., Chen, Y. H., Chang, M. C., Huang, C. T., Liu, C. P., Lau, Y. J., Hwang, K. P., Ko, W-C., Wang, C. T., Liu, C. Y., Liu, C. L., & Hsueh, P. R. (2012). Fusidic acid for the treatment of bone and joint infections caused by meticillin-resistant Staphylococcus aureus. International journal of antimicrobial agents, 40(2), 103-107. https://doi.org/10.1016/j.ijantimicag.2012.03.010