摘要
Background: The relationship between gastroesophageal reflux disease (GERD) and atrial fibrillation (AF) has been previously reported. However, the detailed mechanism remains unknown. In this study, we investigated the effects of acid reflux on the intrinsic cardiac autonomic nervous system, atrial/ventricular electrophysiology, and AF inducibility. Methods: Eighteen rabbits were randomized into three groups: acid reflux (group 1, n = 6), control (group 2, n = 6), and acid reflux with periesophageal vagal blockade (group 3, n = 6). Atrial and ventricular effective refractory periods (ERPs) and AF inducibility were checked at baseline and then hourly until 5 hours after the experiment. Results: Three hours after the experiment, atrial ERP prolongation was noted in groups 2 and 3 (P <.05), whereas shortening of the atrial ERPs was observed in group 1, compared with the baseline. However, no changes were observed in ventricular ERPs in the three groups. The AF inducibility was higher in group 1 than in groups 2 and 3. Pathological examination showed clear esophageal mucosal breaks in groups 1 and 3. Conclusions: In this study, we found that the antimuscarinic blockade prevents GERD induced changes to atrial electrophysiology and susceptibility to AF—making it highly likely that autonomic activity is important in mediating this effect.
| 原文 | English |
|---|---|
| 頁（從 - 到） | 2262-2270 |
| 頁數 | 9 |
| 期刊 | Journal of Cardiovascular Electrophysiology |
| 卷 | 30 |
| 發行號 | 11 |
| DOIs | |
| 出版狀態 | Published - 2019 十一月 1 |
指紋
All Science Journal Classification (ASJC) codes
- Cardiology and Cardiovascular Medicine
- Physiology (medical)
引用此文
}
Gastroesophageal reflux disease and atrial fibrillation : Insight from autonomic cardiogastric neural interaction. / Huang, Ting Chun; Lo, Li Wei; Yamada, Shinya; Chou, Yu Hui; Lin, Wei Lun; Chang, Shih Lin; Lin, Yenn Jiang; Liu, Shin Huei; Cheng, Wen Han; Tsai, Tsung Ying; Liu, Ping Yen; Chen, Shih Ann.
於: Journal of Cardiovascular Electrophysiology, 卷 30, 編號 11, 01.11.2019, p. 2262-2270.研究成果: Article
TY - JOUR
T1 - Gastroesophageal reflux disease and atrial fibrillation
T2 - Insight from autonomic cardiogastric neural interaction
AU - Huang, Ting Chun
AU - Lo, Li Wei
AU - Yamada, Shinya
AU - Chou, Yu Hui
AU - Lin, Wei Lun
AU - Chang, Shih Lin
AU - Lin, Yenn Jiang
AU - Liu, Shin Huei
AU - Cheng, Wen Han
AU - Tsai, Tsung Ying
AU - Liu, Ping Yen
AU - Chen, Shih Ann
PY - 2019/11/1
Y1 - 2019/11/1
N2 - Background: The relationship between gastroesophageal reflux disease (GERD) and atrial fibrillation (AF) has been previously reported. However, the detailed mechanism remains unknown. In this study, we investigated the effects of acid reflux on the intrinsic cardiac autonomic nervous system, atrial/ventricular electrophysiology, and AF inducibility. Methods: Eighteen rabbits were randomized into three groups: acid reflux (group 1, n = 6), control (group 2, n = 6), and acid reflux with periesophageal vagal blockade (group 3, n = 6). Atrial and ventricular effective refractory periods (ERPs) and AF inducibility were checked at baseline and then hourly until 5 hours after the experiment. Results: Three hours after the experiment, atrial ERP prolongation was noted in groups 2 and 3 (P <.05), whereas shortening of the atrial ERPs was observed in group 1, compared with the baseline. However, no changes were observed in ventricular ERPs in the three groups. The AF inducibility was higher in group 1 than in groups 2 and 3. Pathological examination showed clear esophageal mucosal breaks in groups 1 and 3. Conclusions: In this study, we found that the antimuscarinic blockade prevents GERD induced changes to atrial electrophysiology and susceptibility to AF—making it highly likely that autonomic activity is important in mediating this effect.
AB - Background: The relationship between gastroesophageal reflux disease (GERD) and atrial fibrillation (AF) has been previously reported. However, the detailed mechanism remains unknown. In this study, we investigated the effects of acid reflux on the intrinsic cardiac autonomic nervous system, atrial/ventricular electrophysiology, and AF inducibility. Methods: Eighteen rabbits were randomized into three groups: acid reflux (group 1, n = 6), control (group 2, n = 6), and acid reflux with periesophageal vagal blockade (group 3, n = 6). Atrial and ventricular effective refractory periods (ERPs) and AF inducibility were checked at baseline and then hourly until 5 hours after the experiment. Results: Three hours after the experiment, atrial ERP prolongation was noted in groups 2 and 3 (P <.05), whereas shortening of the atrial ERPs was observed in group 1, compared with the baseline. However, no changes were observed in ventricular ERPs in the three groups. The AF inducibility was higher in group 1 than in groups 2 and 3. Pathological examination showed clear esophageal mucosal breaks in groups 1 and 3. Conclusions: In this study, we found that the antimuscarinic blockade prevents GERD induced changes to atrial electrophysiology and susceptibility to AF—making it highly likely that autonomic activity is important in mediating this effect.
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U2 - 10.1111/jce.14181
DO - 10.1111/jce.14181
M3 - Article
C2 - 31515888
AN - SCOPUS:85073931373
VL - 30
SP - 2262
EP - 2270
JO - Journal of Cardiovascular Electrophysiology
JF - Journal of Cardiovascular Electrophysiology
SN - 1045-3873
IS - 11
ER -