Gender-specific association of the SLC6A4 and DRD2 gene variants in bipolar disorder

Tzu Yun Wang, Sheng Yu Lee, Shiou Lan Chen, Yun Hsuan Chang, Shih Heng Chen, San Yuan Huang, Nian Sheng Tzeng, Chen Lin Wang, Pin Hsi Yeh, Kao Chin Chen, I. Hui Lee, Tzung Lieh Yeh, Yen Kuang Yang, Ru Band Lu

研究成果: Article

12 引文 斯高帕斯(Scopus)

摘要

Findings on the association between the risk for developing bipolar disorder and the functions of the serotonin transporter-linked polymorphic region gene (5-HTTLPR) and dopamine D2 receptor gene (DRD2) variants are contradictory. One explanation for this is that a gender difference may exist for genetic contributions. We compared the gender-related main effects and the gene-to-gene interaction between serotonin transporter gene (SLC6A4) and DRD2 in adult male and female patients with bipolar I (BP-I) and bipolar II (BP-II) disorder. Patients with BP-I (n = 400) and BP-II (n = 493), and healthy controls (n = 442) were recruited from Taiwan's Han Chinese population. The genotypes of the 5-HTTLPR and DRD2 Taq-IA polymorphisms were determined using polymerase chain reaction-restriction fragment length polymorphism analysis. Logistic regression analysis showed a significant gender-specific association of the DRD2 A1/A1 and the 5-HTTLPR S/S, S/L G, and L G/LG (S+) (p = 0.01) genotypes in men with BP-I (p = 0.002 and 0.01, respectively) and BP-II (p = 0.001 and 0.007, respectively), but not in women. A significant interaction for the DRD2 A1/A1 and 5-HTTLPR S+ polymorphisms was also found only in men with BP-I and BP-II (p = 0.003 and 0.001, respectively). We provide preliminary evidence for a gender-specific effect of the SLC6A4 and DRD2 gene variants for the risk of BP-I and of BP-II. We also found gender-specific interaction between 5-HTTLPR and DRD2 Taq-IA polymorphisms in patients with bipolar disorder.

原文English
頁(從 - 到)211-222
頁數12
期刊International Journal of Neuropsychopharmacology
17
發行號2
DOIs
出版狀態Published - 2014 二月 1

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Psychiatry and Mental health
  • Pharmacology (medical)

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    Wang, T. Y., Lee, S. Y., Chen, S. L., Chang, Y. H., Chen, S. H., Huang, S. Y., Tzeng, N. S., Wang, C. L., Yeh, P. H., Chen, K. C., Lee, I. H., Yeh, T. L., Yang, Y. K., & Lu, R. B. (2014). Gender-specific association of the SLC6A4 and DRD2 gene variants in bipolar disorder. International Journal of Neuropsychopharmacology, 17(2), 211-222. https://doi.org/10.1017/S1461145713001296