Genetic alterations in oral squamous cell carcinoma of young adults

Ying Tai Jin, J. Myers, Sen Tien Tsai, H. Goepfert, J. G. Batsakis, A. K. El-Naggar

研究成果: Article同行評審

46 引文 斯高帕斯(Scopus)

摘要

The underlying molecular abnormalities associated with head and neck squamous cell carcinoma in young adults (< 40 years) are unknown. We analyzed DNA extracted from paired microdissected samples of normal squamous epithelia and invasive oral squamous cell carcinomas from 36 young adults at microsatellite loci commonly found in older patients and correlated the results with clinicopathologic parameters and outcome. Our results showed that 30 of the 36 (83%) tumors manifest loss of heterozygosity (LOH) in at least one marker. Microsatellite instability was manifested in only six tumors (< 17%). The highest incidences of alterations were noted at markers D9S168 (9p23-22), TP53 (17p13), and D17S799 (17p11) on the short arms of chromosomes 9 and 17. In general, the incidences of LOH at 3, 9 and 17p regions in young adults were similar to those found in older patients. No correlation between LOH at chromosomes 3, 9, and 17p and clinicopathologic parameters was found. Our study indicates that chromosomal regions with frequent genetic alterations involved in young adult squamous tumorigenesis are similar to those reported in older patients. Further studies of other chromosomes in this population are underway to define the novel molecular features of these tumors.

原文English
頁(從 - 到)251-256
頁數6
期刊Oral Oncology
35
發行號3
DOIs
出版狀態Published - 1999 5月 1

All Science Journal Classification (ASJC) codes

  • 口腔外科
  • 腫瘤科
  • 癌症研究

指紋

深入研究「Genetic alterations in oral squamous cell carcinoma of young adults」主題。共同形成了獨特的指紋。

引用此