TY - JOUR
T1 - Genetic and environmental influences on adiponectin, leptin, and BMI among adolescents in Taiwan
T2 - A multivariate twin/sibling analysis
AU - Liu, Pi Hua
AU - Jiang, Yi Der
AU - Chen, Wei J.
AU - Chang, Ching Chung
AU - Lee, Tso Ching
AU - Sun, H. Sunny
AU - Chuang, Lee Ming
N1 - Funding Information:
We thank Mr. Fu-Shiung Lin for expert technical assistance with the biochemical assays, Miss Chia-Lin Chao, Miss Li-Fen Chien, Miss Chien-Yi Chuang, and Miss Chia-Yen Wu for excellent data collection, Mr. Po-Chang Hsiao for helping in compiling relevant data, and especially all our participants for their support. The study was supported in part by National Health Research Institutes (NHRI-CN-MG-9001S), National Science Council (NSC 93-2752-B-0020-009-PAE) of Taiwan, and the National Taiwan University Research Center for Medical Excellence.
PY - 2008/10
Y1 - 2008/10
N2 - Circulating levels of leptin and adiponectin are closely associated with obesity. However, it is not known whether there are common shared genes or environment exerting influences on the levels of leptin, adiponectin, and BMI. We aimed to assess the relative contribution of genes and environment to adiponectin, leptin, and BMI individually as well as simultaneously to the three measures. Our subjects included a total of 228 twin/sibling pairs aged 12 to 18 (130 monozygotic twins, 68 dizygotic twins and 30 sibling pairs) were recruited from the middle schools. Multivariate analyses were applied to twin/sibling data using structural equation modeling. The results showed that intraclass correlations for adiponectin, leptin and BMI were higher in the MZ twins than those in the DZ/SP group. The relative contribution of genes to adiponectin (39%) was comparable to those of shared environment (40%). In contrast, leptin and BMI were influenced mostly by genes (74% and 89%, respectively). The multivariate genetic analyses showed that a latent factor underlying the three measures was identified, with BMI being equivalent to this latent factor. The BMI-dependent genetic factor explains only 15% and 34% of variation of adiponectin and leptin, respectively. These data indicate a differential contribution of genetic factors for the variation of adiponectin, leptin and BMI. More importantly, only a small portion of the genetic influences on adiponectin and leptin was attributed to BMI. Our findings provided more insight into the com - plex regulation of adiponectin and leptin in obesity.
AB - Circulating levels of leptin and adiponectin are closely associated with obesity. However, it is not known whether there are common shared genes or environment exerting influences on the levels of leptin, adiponectin, and BMI. We aimed to assess the relative contribution of genes and environment to adiponectin, leptin, and BMI individually as well as simultaneously to the three measures. Our subjects included a total of 228 twin/sibling pairs aged 12 to 18 (130 monozygotic twins, 68 dizygotic twins and 30 sibling pairs) were recruited from the middle schools. Multivariate analyses were applied to twin/sibling data using structural equation modeling. The results showed that intraclass correlations for adiponectin, leptin and BMI were higher in the MZ twins than those in the DZ/SP group. The relative contribution of genes to adiponectin (39%) was comparable to those of shared environment (40%). In contrast, leptin and BMI were influenced mostly by genes (74% and 89%, respectively). The multivariate genetic analyses showed that a latent factor underlying the three measures was identified, with BMI being equivalent to this latent factor. The BMI-dependent genetic factor explains only 15% and 34% of variation of adiponectin and leptin, respectively. These data indicate a differential contribution of genetic factors for the variation of adiponectin, leptin and BMI. More importantly, only a small portion of the genetic influences on adiponectin and leptin was attributed to BMI. Our findings provided more insight into the com - plex regulation of adiponectin and leptin in obesity.
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U2 - 10.1375/twin.11.5.495
DO - 10.1375/twin.11.5.495
M3 - Article
C2 - 18828732
AN - SCOPUS:56749156946
SN - 1832-4274
VL - 11
SP - 495
EP - 504
JO - Twin Research and Human Genetics
JF - Twin Research and Human Genetics
IS - 5
ER -