Genetic polymorphisms in the prostaglandin pathway genes and risk of head and neck cancer

Wei-Ting Lee, Cheng-Chih Huang, Ken-Chung Chen, Dung-Yau Wang, Chun-Yen Ou, Sen-Tien Tsai, Chia-Jui Yen, Sheen-Yie Fang, H. I. Lo, Yuan-Hua Wu, Wei-Ting Hsueh, Ming-Wei Yang, Forn-Chia Lin, Jenn-Ren Hsiao, Jehn-Shun Huang, Jang-Yang Chang, K. Y. Chang, Shang-Yin Wu, C. L. Lin, Y. H. WangY. L. Weng, H. C. Yang, JS S. Chang

研究成果: Article

1 引文 (Scopus)

摘要

Objective: Previous studies examining the association between genetic variations in prostaglandin pathway and risk of head and neck cancer (HNC) have only included polymorphisms in the PTGS2 (COX2) gene. This study investigated the association between genetic polymorphisms of six prostaglandin pathway genes (PGDS, PTGDS, PTGES, PTGIS, PTGS1 and PTGS2), and risk of HNC. Methods: Interviews regarding the consumption of alcohol, betel quid, and cigarette were conducted with 222 HNC cases and 214 controls. Genotyping was performed for 48 tag and functional single-nucleotide polymorphisms (SNPs). Results: Two tag SNPs of PTGIS showed a significant association with HNC risk [rs522962: log-additive odds ratio (OR) = 1.42, 95% confidence interval (CI): 1.01-1.99 and dominant OR = 1.58, 95% CI: 1.02-2.47; rs6125671: log-additive OR = 1.49, 95% CI: 1.08-2.05 and dominant OR = 1.96, 95% CI: 1.16-3.32]. In addition, a region in PTGIS tagged by rs927068 and rs6019902 was significantly associated with risk of HNC (global P = 0.007). Finally, several SNPs interacted with betel quid and cigarette to influence the risk of HNC. Conclusions: Genetic variations in prostaglandin pathway genes are associated with risk of HNC and may modify the relationship between use of betel quid or cigarette and development of HNC.

原文English
頁(從 - 到)207-215
頁數9
期刊Oral Diseases
21
發行號2
DOIs
出版狀態Published - 2015 三月 1

指紋

Genetic Polymorphisms
Head and Neck Neoplasms
Prostaglandins
Genes
Odds Ratio
Tobacco Products
Confidence Intervals
Single Nucleotide Polymorphism
Cyclooxygenase 2
Alcohol Drinking
Interviews

All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology
  • Dentistry(all)

引用此文

@article{bb9b0650cfdf45e387fff3eb18cf15ad,
title = "Genetic polymorphisms in the prostaglandin pathway genes and risk of head and neck cancer",
abstract = "Objective: Previous studies examining the association between genetic variations in prostaglandin pathway and risk of head and neck cancer (HNC) have only included polymorphisms in the PTGS2 (COX2) gene. This study investigated the association between genetic polymorphisms of six prostaglandin pathway genes (PGDS, PTGDS, PTGES, PTGIS, PTGS1 and PTGS2), and risk of HNC. Methods: Interviews regarding the consumption of alcohol, betel quid, and cigarette were conducted with 222 HNC cases and 214 controls. Genotyping was performed for 48 tag and functional single-nucleotide polymorphisms (SNPs). Results: Two tag SNPs of PTGIS showed a significant association with HNC risk [rs522962: log-additive odds ratio (OR) = 1.42, 95{\%} confidence interval (CI): 1.01-1.99 and dominant OR = 1.58, 95{\%} CI: 1.02-2.47; rs6125671: log-additive OR = 1.49, 95{\%} CI: 1.08-2.05 and dominant OR = 1.96, 95{\%} CI: 1.16-3.32]. In addition, a region in PTGIS tagged by rs927068 and rs6019902 was significantly associated with risk of HNC (global P = 0.007). Finally, several SNPs interacted with betel quid and cigarette to influence the risk of HNC. Conclusions: Genetic variations in prostaglandin pathway genes are associated with risk of HNC and may modify the relationship between use of betel quid or cigarette and development of HNC.",
author = "Wei-Ting Lee and Cheng-Chih Huang and Ken-Chung Chen and Dung-Yau Wang and Chun-Yen Ou and Sen-Tien Tsai and Chia-Jui Yen and Sheen-Yie Fang and Lo, {H. I.} and Yuan-Hua Wu and Wei-Ting Hsueh and Ming-Wei Yang and Forn-Chia Lin and Jenn-Ren Hsiao and Jehn-Shun Huang and Jang-Yang Chang and Chang, {K. Y.} and Shang-Yin Wu and Lin, {C. L.} and Wang, {Y. H.} and Weng, {Y. L.} and Yang, {H. C.} and Chang, {JS S.}",
year = "2015",
month = "3",
day = "1",
doi = "10.1111/odi.12244",
language = "English",
volume = "21",
pages = "207--215",
journal = "Oral Diseases",
issn = "1354-523X",
publisher = "Wiley-Blackwell",
number = "2",

}

TY - JOUR

T1 - Genetic polymorphisms in the prostaglandin pathway genes and risk of head and neck cancer

AU - Lee, Wei-Ting

AU - Huang, Cheng-Chih

AU - Chen, Ken-Chung

AU - Wang, Dung-Yau

AU - Ou, Chun-Yen

AU - Tsai, Sen-Tien

AU - Yen, Chia-Jui

AU - Fang, Sheen-Yie

AU - Lo, H. I.

AU - Wu, Yuan-Hua

AU - Hsueh, Wei-Ting

AU - Yang, Ming-Wei

AU - Lin, Forn-Chia

AU - Hsiao, Jenn-Ren

AU - Huang, Jehn-Shun

AU - Chang, Jang-Yang

AU - Chang, K. Y.

AU - Wu, Shang-Yin

AU - Lin, C. L.

AU - Wang, Y. H.

AU - Weng, Y. L.

AU - Yang, H. C.

AU - Chang, JS S.

PY - 2015/3/1

Y1 - 2015/3/1

N2 - Objective: Previous studies examining the association between genetic variations in prostaglandin pathway and risk of head and neck cancer (HNC) have only included polymorphisms in the PTGS2 (COX2) gene. This study investigated the association between genetic polymorphisms of six prostaglandin pathway genes (PGDS, PTGDS, PTGES, PTGIS, PTGS1 and PTGS2), and risk of HNC. Methods: Interviews regarding the consumption of alcohol, betel quid, and cigarette were conducted with 222 HNC cases and 214 controls. Genotyping was performed for 48 tag and functional single-nucleotide polymorphisms (SNPs). Results: Two tag SNPs of PTGIS showed a significant association with HNC risk [rs522962: log-additive odds ratio (OR) = 1.42, 95% confidence interval (CI): 1.01-1.99 and dominant OR = 1.58, 95% CI: 1.02-2.47; rs6125671: log-additive OR = 1.49, 95% CI: 1.08-2.05 and dominant OR = 1.96, 95% CI: 1.16-3.32]. In addition, a region in PTGIS tagged by rs927068 and rs6019902 was significantly associated with risk of HNC (global P = 0.007). Finally, several SNPs interacted with betel quid and cigarette to influence the risk of HNC. Conclusions: Genetic variations in prostaglandin pathway genes are associated with risk of HNC and may modify the relationship between use of betel quid or cigarette and development of HNC.

AB - Objective: Previous studies examining the association between genetic variations in prostaglandin pathway and risk of head and neck cancer (HNC) have only included polymorphisms in the PTGS2 (COX2) gene. This study investigated the association between genetic polymorphisms of six prostaglandin pathway genes (PGDS, PTGDS, PTGES, PTGIS, PTGS1 and PTGS2), and risk of HNC. Methods: Interviews regarding the consumption of alcohol, betel quid, and cigarette were conducted with 222 HNC cases and 214 controls. Genotyping was performed for 48 tag and functional single-nucleotide polymorphisms (SNPs). Results: Two tag SNPs of PTGIS showed a significant association with HNC risk [rs522962: log-additive odds ratio (OR) = 1.42, 95% confidence interval (CI): 1.01-1.99 and dominant OR = 1.58, 95% CI: 1.02-2.47; rs6125671: log-additive OR = 1.49, 95% CI: 1.08-2.05 and dominant OR = 1.96, 95% CI: 1.16-3.32]. In addition, a region in PTGIS tagged by rs927068 and rs6019902 was significantly associated with risk of HNC (global P = 0.007). Finally, several SNPs interacted with betel quid and cigarette to influence the risk of HNC. Conclusions: Genetic variations in prostaglandin pathway genes are associated with risk of HNC and may modify the relationship between use of betel quid or cigarette and development of HNC.

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U2 - 10.1111/odi.12244

DO - 10.1111/odi.12244

M3 - Article

C2 - 24724948

AN - SCOPUS:84922979047

VL - 21

SP - 207

EP - 215

JO - Oral Diseases

JF - Oral Diseases

SN - 1354-523X

IS - 2

ER -