Genetic susceptibility to lung cancer

Haruhiko Sugimura, Hong Tao, Masaya Suzuki, Hiroki Mori, Masaru Tsuboi, Shun Matsuura, Masanori Goto, Kazuya Shinmura, Takachika Ozawa, Fumihiko Tanioka, Naomi Sato, Yoshitaka Matsushima, Shinji Kageyama, Kazuhito Funai, Pei Hsin Chou, Tomonari Matsuda

研究成果: Article同行評審

16 引文 斯高帕斯(Scopus)


Lung cancer is a highly environmental disease, but cancer researchers have long been interested in investigating genetic susceptibility to lung cancer. This paper is a historical review and provides updated perspectives on lung cancer susceptibility research. The recent introduction of easier genotyping methods and the availability of an almost complete human genome database facilitated the association study to thousands of cases and controls for millions of genetic markers. Discoveries in the field of behavior genetics, that is, the genetic aspects of smoking behavior and nicotine addiction, unexpectedly indicated that polymorphisms in the human central nervous system play an important role in eventually leading to lung cancer. These findings were achieved by using comprehensive approaches, such as a genome, transcriptome, or proteome approach, and the studies were often conducted without a hypothesis. Another-omics approach, the "adductome" or "exposome" approach to how life style information can be integrated into the framework of genetic association studies, has recently emerged. These new paradigms will influence the area of lung cancer risk evaluation in genome cohort studies.

頁(從 - 到)1463-1477
期刊Frontiers in Bioscience - Scholar
3 S
出版狀態Published - 2011 6月 1

All Science Journal Classification (ASJC) codes

  • 一般生物化學,遺傳學和分子生物學
  • 一般免疫學和微生物學


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